Feeling gutted in chronic kidney disease (CKD): Gastrointestinal disorders and therapies to improve gastrointestinal health in individuals CKD, including those undergoing dialysis.

IF 1.4 4区医学 Q3 UROLOGY & NEPHROLOGY

Seminars in Dialysis Pub Date : 2024-07-01 Epub Date: 2021-10-27 DOI:10.1111/sdi.13030

Annabel Biruete, Andrea Shin, Brandon M Kistler, Sharon M Moe

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Abstract

Chronic kidney disease (CKD) affects 9.1% of the population worldwide. CKD may lead to structural and functional gastrointestinal alterations, including impairment in the intestinal barrier, digestion and absorption of nutrients, motility, and changes to the gut microbiome. These changes can lead to increased gastrointestinal symptoms in people with CKD, even in early grades of kidney dysfunction. Gastrointestinal symptoms have been associated with lower quality of life and reduced nutritional status. Therefore, there has been considerable interest in improving gastrointestinal health in this clinical population. Gastrointestinal health can be influenced by lifestyle and medications, particularly in advanced grades of kidney dysfunction. Therapies focused on gastrointestinal health have been studied, including the use of probiotics, prebiotics, and synbiotics, yielding limited and conflicting results. This review summarizes the alterations in the gastrointestinal tract structure and function and provides an overview of potential nutritional interventions that kidney disease professionals can provide to improve gastrointestinal health in individuals with CKD.

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慢性肾脏病（CKD）患者的肠胃不适：慢性肾脏病（CKD）患者（包括透析患者）的胃肠功能紊乱和改善胃肠道健康的疗法。

慢性肾脏病（CKD）影响着全球 9.1% 的人口。慢性肾脏病可能导致胃肠道结构和功能的改变，包括肠道屏障、营养物质的消化和吸收、蠕动和肠道微生物组的改变。这些变化可导致慢性肾功能衰竭患者的胃肠道症状加重，即使在肾功能不全的早期也是如此。胃肠道症状与生活质量下降和营养状况降低有关。因此，人们对改善这一临床人群的胃肠道健康产生了浓厚的兴趣。胃肠道健康会受到生活方式和药物的影响，尤其是在肾功能不全的晚期。针对胃肠道健康的治疗方法包括使用益生菌、益生元和合成益生菌，但研究结果有限且相互矛盾。本综述总结了胃肠道结构和功能的改变，并概述了肾脏病专业人员可提供的潜在营养干预措施，以改善慢性肾脏病患者的胃肠道健康。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Dialysis 医学-泌尿学与肾脏学

CiteScore

3.00

自引率

6.20%

发文量

审稿时长

4-8 weeks

期刊介绍： Seminars in Dialysis is a bimonthly publication focusing exclusively on cutting-edge clinical aspects of dialysis therapy. Besides publishing papers by the most respected names in the field of dialysis, the Journal has unique useful features, all designed to keep you current: -Fellows Forum -Dialysis rounds -Editorials -Opinions -Briefly noted -Summary and Comment -Guest Edited Issues -Special Articles Virtually everything you read in Seminars in Dialysis is written or solicited by the editors after choosing the most effective of nine different editorial styles and formats. They know that facts, speculations, ''how-to-do-it'' information, opinions, and news reports all play important roles in your education and the patient care you provide. Alternate issues of the journal are guest edited and focus on a single clinical topic in dialysis.