Sudden Sensorineural Hearing Loss Is Related to Endothelial Progenitor Cells and Lipoprotein-Associated Phospholipase A2.

IF 1 4区医学 Q3 OTORHINOLARYNGOLOGY

Journal of International Advanced Otology Pub Date : 2023-03-01 DOI:10.5152/iao.2023.21523

Chao Dong, Dong Yang, Peng Zhang, Sitong Guo, Xin Li

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Abstract

Background: This study aimed to investigate the correlation between lipoprotein-associated phospholipase A2, endothelial progenitor cells, and sudden sensorineural hearing loss.

Methods: The number of endothelial progenitor cells and lipoprotein-associated phospholipase A2 levels collected from peripheral blood samples were measured and compared between sudden sensorineural hearing loss group and control group.

Results: The number of endothelial progenitor cells was reduced in sudden sensorineural hearing loss group compared to control group (38.88 ± 10.73 in sudden sensorineural hearing loss group vs. 77.14 ± 8.56 in control group, P <.01). The lipoprotein-associated phospholipase A2 level was markedly increased in sudden sensorineural hearing loss group compared to control group (244.94 ± 59.547 in sudden sensorineural hearing loss group vs. 189.00 ± 50.987 in control group, P <.05).

Conclusion: The number of endothelial progenitor cells was decreased and lipoprotein-associated phospholipase A2 levels were increased in sudden sensorineural hearing loss patients. Changes in the number of endothelial progenitor cells and lipoprotein-associated phospholipase A2 levels may be involved in the pathogenesis of sudden sensorineural hearing loss.

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突发性感觉神经性听力损失与内皮祖细胞和脂蛋白相关磷脂酶A2有关。

背景：本研究旨在探讨脂蛋白相关磷脂酶A2、内皮祖细胞与突发性感音神经性听力损失之间的相关性。方法：测定突发性感音神经性听力损失组和对照组外周血内皮祖细胞数量和脂蛋白相关磷脂酶A2水平，并进行比较。结果：与对照组相比，突发性感音神经性听力损失组的内皮祖细胞数量减少（突感神经性听力损失组为38.88±10.73，对照组为77.14±8.56在突发性感音神经性听力损失的发病机制中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of International Advanced Otology OTORHINOLARYNGOLOGY-

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of International Advanced Otology (IAO – Citation Abbreviation: J Int Adv Otol) is an open access double-blind peer-reviewed, international publication. The Journal of International Advanced Otology is fully sponsored and owned by the European Academy of Otology and Neurotology and the Politzer Society. The Journal of International Advanced Otology is published 3 times per year on April, August, December and its publication language is English. The scope of the Journal is limited with otology, neurotology, audiology (excluding linguistics) and skull base medicine. The Journal of International Advanced Otology aims to publish manuscripts at the highest clinical and scientific level. IAO publishes original articles in the form of clinical and basic research, review articles, short reports and a limited number of case reports. Controversial patient discussions, communications on emerging technology, and historical issues will also be considered for publication.