Use of Capillary Electrophoresis Migration Position for the Presumptive Identification of Hemoglobin Variants Prevalent in China.

IF 1.2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Hemoglobin Pub Date : 2022-11-01 DOI:10.1080/03630269.2022.2151463

Miao Xu, Ming-Yang Li, Yu Zeng, Weijie Xie, An-Ping Xu, Ling Ji

引用次数: 1

Abstract

Capillary electrophoresis (CE) is increasingly being used to screen for hemoglobinopathies. We here report the migration position of hemoglobin (Hb) variants prevalent in China determined by CE. The CE migration position showed excellent precision and minor inter-individual variation. We conclude that the CE migration position can be used as a reliable indicator for identifying Hb variants and can also help to establish a well-characterized library of Hb variants for their refined presumptive identification.

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利用毛细管电泳迁移位置推测中国流行的血红蛋白变异。

毛细管电泳(CE)越来越多地被用于筛查血红蛋白病。我们在此报告了血红蛋白(Hb)变异在中国流行的迁移位置。CE迁移位置精度高，个体间差异小。我们的结论是，CE迁移位置可以作为识别Hb变异的可靠指标，也可以帮助建立一个具有良好特征的Hb变异库，以进行精确的推定鉴定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hemoglobin 医学-生化与分子生物学

CiteScore

1.70

自引率

10.00%

发文量

审稿时长

3 months

期刊介绍： Hemoglobin is a journal in the English language for the communication of research and information concerning hemoglobin in humans and other species. Hemoglobin publishes articles, reviews, points of view The journal covers topics such as: structure, function, genetics and evolution of hemoglobins biochemical and biophysical properties of hemoglobin molecules characterization of hemoglobin disorders (variants and thalassemias), consequences and treatment of hemoglobin disorders epidemiology and prevention of hemoglobin disorders (neo-natal and adult screening) modulating factors methodology used for diagnosis of hemoglobin disorders