Effects of Deep Hyperthermia Combined with Intraperitoneal Chemotherapy on Liver-Kidney Function, Immune Function, and Long-Term Survival in Patients with Abdominal Metastases.

IF 1.2 4区 医学 Q3 EMERGENCY MEDICINE
Emergency Medicine International Pub Date : 2023-04-21 eCollection Date: 2023-01-01 DOI:10.1155/2023/5878402
Yan Zhang, Xiaomin Lu, Haoming Ji, Liangfeng Zheng, Guodong Chen, Ye Qian
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引用次数: 0

Abstract

Objectives: To analyze the effects of deep hyperthermia combined with intraperitoneal chemotherapy on liver-kidney function, immune function, and long-term survival in patients with abdominal metastases.

Methods: A total of 88 patients with abdominal metastases confirmed in the hospital were enrolled as the research objects between August 2018 and August 2021. They were randomly divided into control group (n = 44) and observation group (n = 44). The control group was treated with intraperitoneal chemotherapy, while observation group was additionally treated with deep hyperthermia. The general clinical data of patients were recorded. The short-term and long-term curative effects were evaluated. The occurrence of side effects in both groups was recorded. Before and after treatment, levels of alanine transaminase (ALT) and aspartate transaminase (AST) were detected by full-automatic biochemical analyzer. The level of blood urea nitrogen (BUN) was detected by the urease electrode method. The level of serum creatinine (Scr) was detected by the picric acid method. The levels of CD3 +, CD4 +, CD8 +, and NK cells were detected by BD FACSCalibur flow cytometer.

Results: There was no significant difference in clinical data between the two groups (P > 0.05). In the observation group, ORR was significantly higher than that in the control group (54.55% vs 29.55%) (P < 0.05), OS was significantly longer than that in the control group (P < 0.05), and median survival time and mPFS were longer than those in the control group. After treatment, the levels of ALT, AST, BUN, and Scr were significantly increased in the control group (P < 0.05), but there was no significant difference in peripheral blood CD3 +, CD4 +, and CD4 +/CD8 + ratio or count of NK cells before and after treatment (P > 0.05). Before and after treatment, there was no significant difference in the levels of ALT, AST, BUN, and Scr in the observation group (P > 0.05). After treatment, peripheral blood CD3 +, CD4 +, and CD4 +/CD8 + ratio and count of NK cells were all increased in the observation group, significantly higher than those in the control group (P < 0.05). The incidence of chemotherapy side effects in the observation group was significantly lower than that in the control group (P < 0.05).

Conclusion: The short-term and long-term curative effects of deep hyperthermia combined with intraperitoneal chemotherapy are good on patients with intraperitoneal metastases, with less damage to liver-kidney function. It is beneficial to enhance immune function of patients, with mild side effects.

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深部热疗联合腹腔化疗对腹腔转移瘤患者肝肾功能、免疫功能和长期生存的影响
目的:分析深部热疗联合腹腔化疗对腹腔转移瘤患者肝肾功能、免疫功能和长期生存的影响:分析深部热疗联合腹腔化疗对腹腔转移瘤患者肝肾功能、免疫功能及长期生存的影响:选取2018年8月至2021年8月期间该院确诊的腹腔转移瘤患者共88例作为研究对象。将其随机分为对照组(n=44)和观察组(n=44)。对照组采用腹腔化疗,观察组在此基础上采用深部热疗。记录患者的一般临床数据。评估了短期和长期疗效。记录两组患者的副作用发生情况。治疗前后,全自动生化分析仪检测了丙氨酸转氨酶(ALT)和天门冬氨酸转氨酶(AST)的水平。用尿素酶电极法检测血尿素氮(BUN)水平。血清肌酐(Scr)水平采用苦味酸法检测。用 BD FACSCalibur 流式细胞仪检测 CD3 +、CD4 +、CD8 + 和 NK 细胞的水平:结果:两组临床数据无明显差异(P>0.05)。观察组的ORR明显高于对照组(54.55% vs 29.55%)(P<0.05),OS明显长于对照组(P<0.05),中位生存时间和mPFS均长于对照组。治疗后,对照组的ALT、AST、BUN和Scr水平明显升高(P<0.05),但治疗前后外周血CD3+、CD4+、CD4+/CD8+比值或NK细胞计数无明显差异(P>0.05)。治疗前后,观察组的 ALT、AST、BUN 和 Scr 水平无明显差异(P > 0.05)。治疗后,观察组外周血 CD3 +、CD4 +、CD4 +/CD8 + 比值和 NK 细胞计数均有所增加,明显高于对照组(P < 0.05)。观察组化疗副作用发生率明显低于对照组(P<0.05):结论:深部热疗联合腹腔化疗对腹腔内转移瘤患者的短期和长期疗效均较好,对肝肾功能的损害较小。有利于增强患者的免疫功能,副作用轻微。
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来源期刊
Emergency Medicine International
Emergency Medicine International EMERGENCY MEDICINE-
CiteScore
0.10
自引率
0.00%
发文量
187
审稿时长
17 weeks
期刊介绍: Emergency Medicine International is a peer-reviewed, Open Access journal that provides a forum for doctors, nurses, paramedics and ambulance staff. The journal publishes original research articles, review articles, and clinical studies related to prehospital care, disaster preparedness and response, acute medical and paediatric emergencies, critical care, sports medicine, wound care, and toxicology.
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