The value of soluble suppression of tumorigenesis-2 (sST2) in the maintenance of hemodialysis patients with heart failure.

IF 0.3 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Hippokratia Pub Date : 2022-01-01

X Zhou, F Yi, L Peng, J Jiang, L Lan

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引用次数: 0

Abstract

Background: Patients with end-stage renal disease are prone to develop heart failure (HF). The N-terminal pro-brain natriuretic peptide (NT-proBNP, BNP) is regarded as the gold standard for diagnosing HF. However, its prognostic sensitivity in patients with end-stage renal disease is sub-optimal. Soluble suppression of tumorigenesis-2 (sST2) has been well studied in HF but rarely in patients with maintenance hemodialysis (MHD). This study aimed to evaluate the value of sST2 in predicting HF in MHD patients.

Methods: Twenty-three patients with New York Heart Association (NYHA) class III-IV were included in the HF group and 88 NYHA class I-II patients in the non-heart failure (NHF) group. sST2 and laboratory indexes were compared between the two groups.

Results: The HF group, compared with the NHF group, presented with higher sST2, more advanced age, higher incidence of coronary heart disease (CHD), left ventricle end-diastolic diameter (LVEDD), and pulmonary artery pressure (PAP), and unchanged parathyroid hormone (iPTH). The HF group also had lower ejection fraction (EF), uric acid, inorganic phosphorus, 25-OH VitD3, and serum albumin. Multivariate logistic regression indicated that age, BNP, and sST2 were independent risk factors of HF in MHD patients. Spearman analysis defined that sST2 was positively correlated with PAP (r =0.283, p =0.003) and C-reactive protein (r =0.354, p <0.001); and negatively correlated with sex (r =-0.255, p =0.007), albumin (r =-0.366, p <0.001), uric acid (r =-0.213, p =0.025), 25-OH VitD3 (r =-0.216, p =0.04), calcium (r =-0.219, p =0.021), and inorganic phosphorus (r =-0.256, p =0.007). Receiver operating characteristic curve analysis determined a positive association between BNP and sST2 (r =0.373, p <0.001), with the area under the curve (AUC) of BNP being 0.822 (sensitivity: 0.783, specificity: 0.830) and the AUC of sST2 being 0.841 (sensitivity: 0.913, specificity: 0.761). The AUC of sST2 was 0.841, and the cut-value was 42.840 (sensitivity: 0.913, specificity: 0.761).

Conclusion: sST2 can predict HF in MHD patients and facilitate early diagnosis and prevention of HF in MHD patients. HIPPOKRATIA 2022, 26 (1):19-24.

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可溶性抑瘤因子-2（sST2）在心力衰竭血液透析患者维持中的价值。

背景：终末期肾病患者容易发生心力衰竭（HF）。N-末端脑钠肽原（NT-proBNP，BNP）被认为是诊断HF的金标准。然而，它对终末期肾病患者的预后敏感性是次优的。可溶性肿瘤发生抑制-2（sST2）在HF中得到了很好的研究，但在维持性血液透析（MHD）患者中很少研究。本研究旨在评估sST2在预测MHD患者HF中的价值。方法：23名纽约心脏协会（NYHA）III-IV级患者被纳入HF组，88名NYHA I-II级患者被列入非心力衰竭（NHF）组。比较两组患者的ST2和实验室指标。结果：与NHF组相比，HF组的sST2更高，年龄更大，冠心病（CHD）、左心室舒张末期直径（LVEDD）、肺动脉压（PAP）和甲状旁腺激素（iPTH）的发病率更高。HF组的射血分数（EF）、尿酸、无机磷、25-OH维生素D3和血清白蛋白也较低。多因素logistic回归表明，年龄、BNP和sST2是MHD患者HF的独立危险因素。Spearman分析表明，sST2与PAP（r=0.283，p=0.003）和C反应蛋白（r=0.354，p）呈正相关。结论：sST2可以预测MHD患者的HF，有助于MHD患者HF的早期诊断和预防。HIPPOKRATIA 2022，26（1）：19-24。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hippokratia MEDICINE, GENERAL & INTERNAL-

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Hippokratia journal is a quarterly issued, open access, peer reviewed, general medical journal, published in Thessaloniki, Greece. It is a forum for all medical specialties. The journal is published continuously since 1997, its official language is English and all submitted manuscripts undergo peer review by two independent reviewers, assigned by the Editor (double blinded review process). Hippokratia journal is managed by its Editorial Board and has an International Advisory Committee and over 500 expert Reviewers covering all medical specialties and additionally Technical Reviewers, Statisticians, Image processing Experts and a journal Secretary. The Society “Friends of Hippokratia Journal” has the financial management of both the printed and electronic edition of the journal.