Outcomes of mechanical ventilation in COVID-19 pregnant patients.

IF 0.3 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL
Hippokratia Pub Date : 2022-01-01
S Mihajlovic, P Savic, N Potparevic, M Lackovic
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引用次数: 0

Abstract

Background: Pregnancy poses a risk factor for respiratory infections due to hormonal changes, reduced tolerance to hypoxia, immunodeficiency, and increased susceptibility towards viral infections. Pregnant women might develop a broad spectrum of clinical conditions associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, from asymptomatic to potentially life-threatening complications. Critical respiratory failure associated with the progression of viral pneumonia is the most severe complication of the coronavirus disease (COVID-19). In some cases, it may require intubation and invasive mechanical ventilation.

Case series: In this case series, we evaluated the outcomes and clinical features of eight critically ill pregnant patients requiring invasive mechanical ventilation during treatment. The most commonly observed symptoms were fever at admission to the hospital, cough, difficulty breathing, and fatigue. Less frequently observed were sore throat and loss of smell and taste. All patients had anemia, and hypertension was the second most common comorbidity in pregnancy. Pregnant patients with lethal outcomes were older than those who recovered. They had higher body mass index values, more symptoms at admission, and higher C-reactive protein values and ferritin levels. Acute Respiratory Distress Syndrome (ARDS) was diagnosed in five cases, and none of these patients survived.

Conclusion: Obesity, maternal age, and diagnosis of ARDS were most commonly observed in our group of patients with lethal outcomes. Preventive measurements, counseling, and enlightenment of potential risk factors, such as obesity, advanced maternal age, and pregnancy-related comorbidities, should be the cornerstones in crises such as COVID-19 when medical care and resources are limited or restricted. HIPPOKRATIA 2022, 26 (1):32-37.

新冠肺炎妊娠患者的机械通气结果。
背景:由于激素变化、对缺氧的耐受性降低、免疫缺陷和对病毒感染的易感性增加,妊娠是呼吸道感染的危险因素。孕妇可能会出现与严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)感染相关的广泛临床症状,从无症状到可能危及生命的并发症。与病毒性肺炎进展相关的严重呼吸衰竭是冠状病毒疾病(新冠肺炎)最严重的并发症。在某些情况下,可能需要插管和有创机械通气。病例系列:在本病例系列中,我们评估了8名在治疗期间需要有创机械通气的危重妊娠患者的结果和临床特征。最常见的症状是入院时发烧、咳嗽、呼吸困难和疲劳。较少观察到的是喉咙痛、嗅觉和味觉丧失。所有患者都有贫血,高血压是妊娠期第二常见的合并症。有致命后果的孕妇年龄大于康复者。他们的体重指数值更高,入院时症状更多,C反应蛋白值和铁蛋白水平更高。5例患者被诊断为急性呼吸窘迫综合征(ARDS),但没有一例存活下来。结论:肥胖、母亲年龄和ARDS的诊断在我们这组有致命后果的患者中最常见。在医疗护理和资源有限或受到限制的情况下,预防措施、咨询和潜在风险因素的启示,如肥胖、高龄产妇和妊娠相关合并症,应成为新冠肺炎等危机的基石。海马2022,26(1):32-37。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Hippokratia
Hippokratia MEDICINE, GENERAL & INTERNAL-
CiteScore
1.10
自引率
0.00%
发文量
0
审稿时长
6-12 weeks
期刊介绍: Hippokratia journal is a quarterly issued, open access, peer reviewed, general medical journal, published in Thessaloniki, Greece. It is a forum for all medical specialties. The journal is published continuously since 1997, its official language is English and all submitted manuscripts undergo peer review by two independent reviewers, assigned by the Editor (double blinded review process). Hippokratia journal is managed by its Editorial Board and has an International Advisory Committee and over 500 expert Reviewers covering all medical specialties and additionally Technical Reviewers, Statisticians, Image processing Experts and a journal Secretary. The Society “Friends of Hippokratia Journal” has the financial management of both the printed and electronic edition of the journal.
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