Paediatric head and neck malignant neoplasms: A brazilian retrospective study.

IF 2.2 3区 医学
W-A Cunha, A-C Corazza, K-M Rezende, M Bönecker, M Gallottini
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Abstract

Background: To assess the prevalence of oral and maxillofacial malignant neoplasias in children and adolescents diagnosed through biopsies sent to the Oral Pathology Laboratory at the University of Sao Paulo School of Dentistry.

Material and methods: A retrospective analysis of anatomopathological reports on patients between 1 and 18 years old issued by the oral and maxillofacial pathology laboratory between 1997 and 2021 was performed for demographic data, lesion site, type of biopsy, diagnostic hypothesis and final diagnosis.

Results: The laboratory issued 76,194 anatomopathological reports during this period, of which 10.77% were of children and adolescents. Of this total, only 32 biopsies (32/8.204; 0.39%) were neoplasias in children and adolescents. Sarcomas were the most prevalent malignant neoplasms (19/32; 59%), followed by carcinomas (7/32; 22%), lymphomas (5/32; 16%) and ganglioneuroblastomas (1/32; 3%). Of these 32 patients, the most affected individuals were aged between 4 and 11 years old (47%), 18 (56%) were male, and the mandible was the main anatomical site involved (28%). In 41% of the cases (13/32), the diagnostic hypothesis of the biopsied lesion was mistakenly considered benign and there was no diagnostic hypothesis in 18% of the cases.

Conclusions: Oral and maxillofacial malignant neoplasms in children and adolescents are uncommon and the accuracy of provisional diagnoses is low in these cases. Better knowledge on oral and maxillofacial malignant lesions in this population would help professionals to reduce the diagnostic time and consequently improve the patient's prognosis.

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儿童头颈部恶性肿瘤:巴西回顾性研究。
背景:评估儿童和青少年口腔颌面部恶性肿瘤的患病率,这些儿童和青少年的口腔和颌面部恶性肿瘤是通过送到圣保罗大学牙科学院口腔病理实验室的活检诊断出来的。材料与方法:回顾性分析1997 - 2021年口腔颌面病理实验室发表的1 ~ 18岁患者的解剖病理报告,包括人口学资料、病变部位、活检类型、诊断假设和最终诊断。结果:实验室在此期间共发表解剖病理报告76,194份,其中儿童和青少年占10.77%。其中,只有32例活组织检查(32/8.204;0.39%)为儿童和青少年的肿瘤。肉瘤是最常见的恶性肿瘤(19/32;59%),其次是癌症(7/32;22%),淋巴瘤(5/32;16%)和神经节神经母细胞瘤(1/32;3%)。32例患者中,年龄在4 ~ 11岁的患者最多(47%),男性18例(56%),下颌骨为主要受累解剖部位(28%)。在41%的病例(13/32)中,活检病变的诊断假设被错误地认为是良性的,18%的病例没有诊断假设。结论:口腔颌面部恶性肿瘤在儿童和青少年中并不常见,其临时诊断的准确性较低。更好的了解口腔颌面部恶性病变,有助于专业人员减少诊断时间,从而改善患者的预后。
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来源期刊
CiteScore
4.50
自引率
0.00%
发文量
52
期刊介绍: 1. Oral Medicine and Pathology: Clinicopathological as well as medical or surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, as well as orofacial neurological disorders, and systemic conditions with an impact on the oral cavity. 2. Oral Surgery: Surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, teeth, implants, oral surgical procedures. Surgical management of diseases affecting head and neck areas. 3. Medically compromised patients in Dentistry: Articles discussing medical problems in Odontology will also be included, with a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients. 4. Implantology 5. Periodontology
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