Association between Interactions among ACE Gene Polymorphisms and Essential Hypertension in Patients in the Hefei Region, Anhui, China.

IF 2.1 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of the Renin-Angiotensin-Aldosterone System Pub Date : 2023-01-01 DOI:10.1155/2023/1159973

Li Wang, Ting-Ting Song, Chang-Wu Dong

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引用次数: 1

Abstract

Objective: Essential hypertension (EH) is a common cardiovascular disease that endangers human health. Its pathogenesis is complex and has not been fully elucidated. We explore the association between EH and interactions among polymorphisms of the angiotensin converting enzyme (ACE) gene in the Hefei region, Anhui, China.

Methods: A total of 500 participants (400 hypertensive and 100 normotensive) were included in this study. The polymorphisms were detected via improved multiple ligase detection reaction (iMLDR). To improve the accuracy of prediction, multifactor dimensionality reduction (MDR) was used to analyze the overall effect of interactions among seven loci on the incidence of EH.

Results: The frequencies of polymorphisms in the ACE genes rs12709426, rs4291, rs4309, rs4331, rs4343, rs4459609, and rs4461142 in the EH group were not statistically significantly different from those in the control group. We also found that the single nucleotide polymorphism (SNP) rs12709426 only had a homozygous AA genotype and no polymorphisms. There were no differences in the frequency of genetic polymorphisms between the EH and control groups. The best model explaining the EH group was the combined effect of ACE genes rs4291, rs4309, and rs4461142.

Conclusion: There is an interaction effect among ACE gene loci in EH patients in Hefei region, Anhui, China. Also, the ACE gene SNP rs12709426 only has a homozygous AA genotype and does not show an association with EH.

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中国安徽合肥地区ACE基因多态性相互作用与原发性高血压的关系

目的:原发性高血压(EH)是一种危害人类健康的常见心血管疾病。其发病机制复杂，尚未完全阐明。我们探讨了中国安徽合肥地区EH与血管紧张素转换酶(ACE)基因多态性相互作用之间的关系。方法:本研究共纳入500例受试者(高血压患者400例，正常血压患者100例)。通过改进的多连接酶检测反应(iMLDR)检测多态性。为了提高预测的准确性，采用多因素降维法分析7个基因座间相互作用对EH发病率的总体影响。结果:EH组ACE基因rs12709426、rs4291、rs4309、rs4331、rs4343、rs4459609、rs4461142的多态性频率与对照组比较，差异均无统计学意义。我们还发现单核苷酸多态性(SNP) rs12709426只有纯合的AA基因型，没有多态性。EH组和对照组之间的遗传多态性频率没有差异。解释EH组的最佳模型是ACE基因rs4291、rs4309和rs4461142的联合作用。结论:安徽合肥地区EH患者的ACE基因位点之间存在交互作用。此外，ACE基因SNP rs12709426仅具有纯合的AA基因型，与EH没有关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Renin-Angiotensin-Aldosterone System 医学-外周血管病

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： JRAAS is a peer-reviewed, open access journal, serving as a resource for biomedical professionals, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals. It publishes original research and reviews on the normal and abnormal function of this system and its pharmacology and therapeutics, mostly in a cardiovascular context but including research in all areas where this system is present, including the brain, lungs and gastro-intestinal tract.