The role of diet in shaping human gut microbiota

IF 3.2 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Best Practice & Research Clinical Gastroenterology Pub Date : 2023-02-01 DOI:10.1016/j.bpg.2023.101828

Emanuele Rinninella , Ege Tohumcu , Pauline Raoul , Marcello Fiorani , Marco Cintoni , Maria Cristina Mele , Giovanni Cammarota , Antonio Gasbarrini , Gianluca Ianiro

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引用次数: 15

Abstract

Gut microbiota plays a fundamental role within human health, and exerts key functions within the human body. Diet is one of the most powerful modulators of gut microbiota functions and composition. This complex interplay involves also the immune system and the intestinal barrier, highlighting the central role of diet in the pathogenesis and treatment of multiple diseases.

In this review article we will paint the landscape of the effects of specific dietary nutrients, and of the detrimental or beneficial outcomes of different dietary patterns, on the composition of human gut microbiota. Moreover, we will discuss the potential application of diet as a therapeutic modulator of gut microbiota, including cutting-edge ways of exploitation, including the use of dietary components as adjuvants to promote microbial engraftment after fecal microbiota transplantation, or personalized nutritional approaches, targeted to the patient microbiome.

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饮食在塑造人体肠道菌群中的作用

肠道微生物群在人类健康中发挥着重要作用，并在人体内发挥着关键作用。饮食是肠道微生物群功能和组成最强大的调节剂之一。这种复杂的相互作用还涉及免疫系统和肠道屏障，突出了饮食在多种疾病的发病机制和治疗中的核心作用。在这篇综述文章中，我们将描绘特定饮食营养素对人类肠道微生物群组成的影响，以及不同饮食模式的有害或有益结果。此外，我们将讨论饮食作为肠道微生物群治疗调节剂的潜在应用，包括尖端的开发方法，包括在粪便微生物群移植后使用饮食成分作为佐剂促进微生物植入，或针对患者微生物群的个性化营养方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Best Practice & Research Clinical Gastroenterology 医学-胃肠肝病学

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

69 days

期刊介绍： Each topic-based issue of Best Practice & Research Clinical Gastroenterology will provide a comprehensive review of current clinical practice and thinking within the specialty of gastroenterology.