Human papillomavirus-specific antibody status among unvaccinated subjects in the region of Vojvodina, Serbia.

IF 1.1 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Central European journal of public health Pub Date : 2023-03-01 DOI:10.21101/cejph.a7257

Gordana Kovačević, Biljana Božić Nedeljković, Aleksandra Patić, Jelena Radovanov, Ivana Hrnjaković-Cvjetković

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引用次数: 0

Abstract

Objectives: The aim of the study was to evaluate the immune status of young people from the Vojvodina province, Serbia, through the detection of IgG antibodies specific for the L1 protein of HPV types 6, 11, 16, and 18 contained in quadrivalent vaccine.

Methods: The study enrolled 514 healthy persons of both genders, aged between 18 and 30 years. All potential participants were informed about the project's aims by trained interviewers before venous blood collection. Also, participants completed a specially designed anonymous questionnaire to identify socio-demographic characteristics and individual behaviours associated with HPV seroprevalence. VPL HPV L1-specific IgG antibodies were measured using a semi-quantitative HPV IgG ELISA kit (Dia.Pro, Italy).

Results: A total of 472 (91.8%) young subjects had no detectable antibodies against high- and low-risk HPV types covered by the quadrivalent vaccine. A slightly higher number of seropositive individuals were detected in the age group of 26-30 years compared to younger than 25. Multivariate analysis showed that the number of lifetime sexual partners was the most powerful predictor of HPV seropositivity (OR = 3.483, 95% CI: 1.294-9.379).

Conclusions: Obtained data point out low levels of naturally induced HPV-specific serum antibodies among the target population in the Vojvodina province. The present work highlights the significance and potential benefits of HPV vaccination. Routine HPV vaccination should be the public health priority in our country and should be included in the national immunization programme as soon as possible.

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塞尔维亚伏伊伏丁那地区未接种疫苗受试者的人乳头瘤病毒特异性抗体状况

目的:本研究的目的是通过检测四价疫苗中含有的HPV 6、11、16和18型L1蛋白特异性IgG抗体，评估塞尔维亚伏伊伏丁那省年轻人的免疫状况。方法:该研究招募了514名年龄在18至30岁之间的男女健康人。在静脉血采集之前，所有潜在的参与者都被训练有素的采访者告知了该项目的目的。此外，参与者还完成了一份专门设计的匿名问卷，以确定与HPV血清阳性率相关的社会人口学特征和个人行为。采用半定量HPV IgG ELISA试剂盒检测VPL HPV l1特异性IgG抗体。亲,意大利)。结果:共有472名(91.8%)年轻受试者未检测到针对四价疫苗覆盖的高危和低危HPV类型的抗体。在26-30岁年龄组中检测到的血清阳性个体数量略高于25岁以下年龄组。多因素分析显示，终生性伴侣的数量是HPV血清阳性的最有力预测因子(OR = 3.483, 95% CI: 1.294-9.379)。结论:获得的数据指出，在伏伊伏丁那省的目标人群中，自然诱导的hpv特异性血清抗体水平较低。目前的工作强调了HPV疫苗接种的重要性和潜在益处。常规HPV疫苗接种应是我国公共卫生工作的重点，并应尽快纳入国家免疫规划。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Central European journal of public health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： The Journal publishes original articles on disease prevention and health protection, environmental impacts on health, the role of nutrition in health promotion, results of population health studies and critiques of specific health issues including intervention measures such as vaccination and its effectiveness. The review articles are targeted at providing up-to-date information in the sphere of public health. The Journal is geographically targeted at the European region but will accept specialised articles from foreign sources that contribute to public health issues also applicable to the European cultural milieu.