Heterogeneity of adipose tissue-resident macrophages-beyond M1/M2 paradigm.

IF 1.3 Q4 ENDOCRINOLOGY & METABOLISM

Diabetology International Pub Date : 2023-04-03 eCollection Date: 2023-04-01 DOI:10.1007/s13340-023-00624-2

Allah Nawaz, Shiho Fujisaka, Tomonobu Kado, Ishtiaq Jeelani, Kazuyuki Tobe

引用次数: 0

Abstract

Adipose tissue-resident macrophages (ATMs) are reported to be important for maintaining adipose tissue remodeling and homeostasis. ATMs were classified for the first time in 2007 into the M1 and M2 types. This theory suggests that in the non-obese adipose tissue, the anti-inflammatory, alternatively activated macrophages (AAMs) predominate, and regulate tissue homeostasis, remodeling, and insulin sensitivity. On the other hand, classically activated M1-type macrophages increase rapidly in obesity, secrete inflammatory cytokines, such as TNFα and IL-6, and induce insulin resistance. In recent years, experimental findings that cannot be explained by this theory have been clarified one after another and the theory is being reconsidered. In this review, based on recent findings, we summarize reports on the novel metabolic regulatory functions of ATMs beyond the M1/M2 paradigm.

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脂肪组织驻留巨噬细胞的异质性--超越 M1/M2 范式。

据报道，脂肪组织驻留巨噬细胞（ATMs）对维持脂肪组织重塑和稳态非常重要。2007 年，ATMs 首次被分为 M1 和 M2 两种类型。该理论认为，在非肥胖的脂肪组织中，抗炎的替代活化巨噬细胞（AAMs）占主导地位，并调节组织的稳态、重塑和胰岛素敏感性。另一方面，经典活化的 M1 型巨噬细胞在肥胖时迅速增加，分泌 TNFα 和 IL-6 等炎性细胞因子，并诱发胰岛素抵抗。近年来，该理论无法解释的实验结果相继得到澄清，该理论正在被重新考虑。在这篇综述中，我们根据最近的研究结果，总结了在 M1/M2 范式之外有关 ATMs 新的代谢调控功能的报道。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetology International ENDOCRINOLOGY & METABOLISM-

CiteScore

3.90

自引率

4.50%

发文量

期刊介绍： Diabetology International, the official journal of the Japan Diabetes Society, publishes original research articles about experimental research and clinical studies in diabetes and related areas. The journal also presents editorials, reviews, commentaries, reports of expert committees, and case reports on any aspect of diabetes. Diabetology International welcomes submissions from researchers, clinicians, and health professionals throughout the world who are interested in research, treatment, and care of patients with diabetes. All manuscripts are peer-reviewed to assure that high-quality information in the field of diabetes is made available to readers. Manuscripts are reviewed with due respect for the author''s confidentiality. At the same time, reviewers also have rights to confidentiality, which are respected by the editors. The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.