Giant malignant phyllodes tumor with distant metastases: a case report and review of the literature.

IF 0.3 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Hippokratia Pub Date : 2022-01-01

A Syrnioti, T Koletsa, S Netta, A Gkoudina, D Paramythiotis

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引用次数: 0

Abstract

Background: Phyllodes tumors (PTs) represent a rare type of breast tumor and are classified into benign, borderline, and malignant. Giant PTs, meaning those sized more than ten cm, are even rarer, most commonly malignant, and usually have a dismal prognosis due to the high metastatic potential.

Case report: We report the case of a 55-year-old woman who underwent modified radical mastectomy and left axillary lymphadenectomy for a rapidly growing, giant, ulcerated mass of the left breast. Histopathologic examination revealed a malignant phyllodes tumor (MPT). Over one year after the initial surgery, the patient was found to have extensive thoracic and retroperitoneal metastases.

Conclusion: Although giant PTs are uncommon, clinical suspicion should be high in rapidly growing breast mass patients. A comprehensive review of all metastatic giant MPT cases reported in the English literature emphasizes the lack of consensus regarding appropriate treatment. In the case of metastatic foci, pathologists need to be aware of the previous history to make a definitive diagnosis. Also, a comparative histopathologic study of the primary and metastatic tumors is sometimes necessary. HIPPOKRATIA 2022, 26 (1):41-45.

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远处转移的巨大恶性叶状肿瘤：一例报告并文献复习。

背景：叶状肿瘤是一种罕见的乳腺肿瘤，分为良性、交界性和恶性。巨大的PT，即大小超过10厘米的PT，更为罕见，最常见的是恶性的，由于转移潜力高，通常预后不佳。病例报告：我们报告了一例55岁的女性，她接受了改良根治性乳房切除术和左腋窝淋巴结切除术，治疗左乳房快速生长的巨大溃疡肿块。组织病理学检查显示为恶性叶状肿瘤（MPT）。初次手术后一年多，患者被发现有广泛的胸部和腹膜后转移。结论：尽管巨大的PT并不常见，但在快速生长的乳腺肿块患者中，临床怀疑应该很高。对英国文献中报道的所有转移性巨大MPT病例的全面综述强调，在适当的治疗方面缺乏共识。在转移灶的情况下，病理学家需要了解既往病史才能做出明确诊断。此外，对原发性和转移性肿瘤进行比较组织病理学研究有时是必要的。海马2022，26（1）：41-45。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hippokratia MEDICINE, GENERAL & INTERNAL-

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Hippokratia journal is a quarterly issued, open access, peer reviewed, general medical journal, published in Thessaloniki, Greece. It is a forum for all medical specialties. The journal is published continuously since 1997, its official language is English and all submitted manuscripts undergo peer review by two independent reviewers, assigned by the Editor (double blinded review process). Hippokratia journal is managed by its Editorial Board and has an International Advisory Committee and over 500 expert Reviewers covering all medical specialties and additionally Technical Reviewers, Statisticians, Image processing Experts and a journal Secretary. The Society “Friends of Hippokratia Journal” has the financial management of both the printed and electronic edition of the journal.