Role of Low-FODMAP diet in functional dyspepsia: “Why”, “When”, and “to Whom”

IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Francesco Rettura , Christian Lambiase , Antonio Grosso , Alessandra Rossi , Riccardo Tedeschi , Linda Ceccarelli , Massimo Bellini
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引用次数: 0

Abstract

Functional dyspepsia (FD) is a frequent disorder of gut-brain interaction, affecting 5–7% of people globally, with significant impairment in quality of life. The management of FD is challenging due to the lack of specific therapeutic approaches.

Although food seems to play a role in symptom production, its pathophysiologic role in patients with FD is not fully understood. Most FD patients report that their symptoms are triggered by food, especially in the post-prandial distress syndrome (PDS) group, although evidence to support the use of dietary interventions are limited.

FODMAPs can increase production of gas in the intestinal lumen, through fermentation by intestinal bacteria, can exert osmotic effects by increasing water volume and can cause an excessive production of short-chain fatty acids (propionate, butyrate, and acetate).

Emerging scientific evidence, confirmed by recent clinical trials, suggest that FODMAPs could be involved in the pathogenesis of FD. Given the consolidated approach of the Low-FODMAP Diet (LFD) in irritable bowel syndrome (IBS) management and emerging scientific evidence regarding the LFD in FD, a therapeutic role of this diet may be hypothesized also in FD, either alone or in combination with other therapies.

低fodmap饮食在功能性消化不良中的作用:“为什么”、“何时”和“对谁”
功能性消化不良(FD)是一种常见的肠脑互动障碍,影响全球5-7%的人,生活质量显著受损。由于缺乏特定的治疗方法,FD的管理具有挑战性。尽管食物似乎在症状产生中发挥作用,但其在FD患者中的病理生理作用尚不完全清楚。大多数FD患者报告说,他们的症状是由食物引发的,尤其是在餐后窘迫综合征(PDS)组,尽管支持使用饮食干预的证据有限。FODMAPs可以通过肠道细菌的发酵增加肠腔内气体的产生,通过增加水量发挥渗透作用,并导致短链脂肪酸(丙酸盐、丁酸盐和乙酸盐)的过量产生。最近的临床试验证实了新出现的科学证据,表明FODMAPs可能参与FD的发病机制。鉴于低FODMAP饮食(LFD)在肠易激综合征(IBS)管理中的综合方法,以及关于LFD在FD中的新科学证据,可以假设这种饮食在FD中也有治疗作用,无论是单独还是与其他疗法联合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.50
自引率
0.00%
发文量
23
审稿时长
69 days
期刊介绍: Each topic-based issue of Best Practice & Research Clinical Gastroenterology will provide a comprehensive review of current clinical practice and thinking within the specialty of gastroenterology.
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