The prevalence of latent/chronic infection in liver transplant candidates in Taleghani Hospital of Tehran, Iran, from 2020 until 2021.

Q3 Medicine

Gastroenterology and Hepatology From Bed to Bench Pub Date : 2023-01-01 DOI:10.22037/ghfbb.v16i1.2664

Amirhassan Rabbani, Hesameddin Eghlimi, Mina Khoshkbarforoushan, Mana Baziboroun

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Abstract

Aim: The present study aimed to study the prevalence of various latent infections in pre-transplanted patients.

Background: Due to chronic immunosuppressive therapy, patients receiving organ transplants are at risk for reactivation of various infections. Due to the complications in the course of diagnosing and treating the post-transplant infection, screening transplant recipients and donors is vital.

Methods: This retrospective cohort study was performed between March 2020 and 2021. A total of 193 patients receiving a liver transplant in Taleghani Hospital, Tehran, Iran were enrolled.

Results: One-hundred and three (53.4%) patients were men, with an average age of 48.4 ± 13.3 years. Among viruses, 177 (91.7%) patients had a positive IgG titer for CMV. Anti-EBV IgG was positive in 169 (87.6%) patients. One-hundred and seventy-five (90.7%) patients had a positive IgG titer for the VZV. One-hundred and sixty-six (86.0%) cases had positive IgG anti-HSV antibodies. According to our findings, none of the patients were infected with HIV, but 9 (4.7%) cases and 141 (73.1%) had positive anti-HCV and anti-HAV IgG antibodies, respectively. HBV surface (HBs) antigen was also reported positive in 17 (8.8%) patients, while the HBs antibody was positive in 29 (15.0%) patients.

Conclusion: In our study, most of the patients had positive serology for latent viral infections such as CMV, EBV, VZV, and HSV, but the prevalence of latent tuberculosis and viral hepatitis was low among transplant candidates.

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2020年至2021年，伊朗德黑兰Taleghani医院肝移植候选者中潜伏/慢性感染的患病率

目的:本研究旨在了解移植前患者各种潜伏感染的流行情况。背景:由于慢性免疫抑制治疗，接受器官移植的患者有各种感染再激活的危险。由于移植后感染在诊断和治疗过程中的并发症，筛选移植受体和供体是至关重要的。方法:该回顾性队列研究于2020年3月至2021年3月进行。共有193名患者在伊朗德黑兰的Taleghani医院接受肝脏移植。结果:男性103例(53.4%)，平均年龄48.4±13.3岁。病毒中有177例(91.7%)CMV IgG滴度阳性。抗ebv IgG阳性169例(87.6%)。175例(90.7%)患者VZV IgG抗体阳性。抗hsv抗体IgG阳性166例(86.0%)。结果显示，所有患者均未感染HIV，但抗hcv抗体阳性9例(4.7%)，抗hav抗体阳性141例(73.1%)。HBV表面抗原(HBs)阳性17例(8.8%)，HBs抗体阳性29例(15.0%)。结论:在我们的研究中，大多数患者的CMV、EBV、VZV和HSV等潜伏病毒感染的血清学阳性，但在移植候选人中潜伏结核和病毒性肝炎的患病率较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastroenterology and Hepatology From Bed to Bench Medicine-Gastroenterology

CiteScore

2.30

自引率

0.00%

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