Implantable biosensors for musculoskeletal health.

IF 2.8 4区医学 Q3 CELL BIOLOGY

Connective Tissue Research Pub Date : 2022-05-01 DOI:10.1080/03008207.2022.2041002

Kylie E Nash, Keat Ghee Ong, Robert E Guldberg

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引用次数: 1

Abstract

Purpose: A healthy musculoskeletal system requires complex functional integration of bone, muscle, cartilage, and connective tissues responsible for bodily support, motion, and the protection of vital organs. Conditions or injuries to musculoskeeltal tissues can devastate an individual's quality of life. Some conditions that are particularly disabling include severe bone and muscle injuries to the extremities and amputations resulting from unmanageable musculoskeletal conditions or injuries. Monitoring and managing musculoskeletal health is intricate because of the complex mechanobiology of these interconnected tissues.

Methods: For this article, we reviewed literature on implantable biosensors related to clinical data of the musculoskeletal system, therapeutics for complex bone injuries, and osseointegrated prosthetics as example applications.

Results: As a result, a brief summary of biosensors technologies is provided along with review of noteworthy biosensors and future developments needed to fully realize the translational benefit of biosensors for musculoskeletal health.

Conclusions: Novel implantable biosensors capable of tracking biophysical parameters in vivo are highly relevant to musculoskeletal health because of their ability to collect clinical data relevant to medical decisions, complex trauma treatment, and the performance of osseointegrated prostheses.

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用于肌肉骨骼健康的植入式生物传感器。

目的:健康的肌肉骨骼系统需要骨骼、肌肉、软骨和结缔组织的复杂功能整合，这些组织负责身体的支撑、运动和重要器官的保护。肌肉骨骼组织的状况或损伤会破坏一个人的生活质量。一些特别致残的情况包括四肢严重的骨骼和肌肉损伤，以及由于无法控制的肌肉骨骼状况或损伤而导致的截肢。监测和管理肌肉骨骼健康是复杂的，因为这些相互联系的组织复杂的机械生物学。方法:本文综述了植入式生物传感器在肌肉骨骼系统、复杂骨损伤治疗和骨整合修复等方面的临床应用。结果:因此，简要总结了生物传感器技术，并回顾了值得注意的生物传感器和充分实现生物传感器对肌肉骨骼健康的转化效益所需的未来发展。结论:新型植入式生物传感器能够跟踪体内生物物理参数，与肌肉骨骼健康高度相关，因为它们能够收集与医疗决策、复杂创伤治疗和骨整合假体性能相关的临床数据。

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来源期刊

Connective Tissue Research 生物-细胞生物学

CiteScore

6.60

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： The aim of Connective Tissue Research is to present original and significant research in all basic areas of connective tissue and matrix biology. The journal also provides topical reviews and, on occasion, the proceedings of conferences in areas of special interest at which original work is presented. The journal supports an interdisciplinary approach; we present a variety of perspectives from different disciplines, including Biochemistry Cell and Molecular Biology Immunology Structural Biology Biophysics Biomechanics Regenerative Medicine The interests of the Editorial Board are to understand, mechanistically, the structure-function relationships in connective tissue extracellular matrix, and its associated cells, through interpretation of sophisticated experimentation using state-of-the-art technologies that include molecular genetics, imaging, immunology, biomechanics and tissue engineering.