Tendon Aging.

Q1 Biochemistry, Genetics and Molecular Biology

Sub-cellular biochemistry Pub Date : 2023-01-01 DOI:10.1007/978-3-031-26576-1_7

Ana Luísa Graça, Manuel Gomez-Florit, Manuela Estima Gomes, Denitsa Docheva

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引用次数: 1

Abstract

Tendons are mechanosensitive connective tissues responsible for the connection between muscles and bones by transmitting forces that allow the movement of the body, yet, with advancing age, tendons become more prone to degeneration followed by injuries. Tendon diseases are one of the main causes of incapacity worldwide, leading to changes in tendon composition, structure, and biomechanical properties, as well as a decline in regenerative potential. There is still a great lack of knowledge regarding tendon cellular and molecular biology, interplay between biochemistry and biomechanics, and the complex pathomechanisms involved in tendon diseases. Consequently, this reflects a huge need for basic and clinical research to better elucidate the nature of healthy tendon tissue and also tendon aging process and associated diseases. This chapter concisely describes the effects that the aging process has on tendons at the tissue, cellular, and molecular levels and briefly reviews potential biological predictors of tendon aging. Recent research findings that are herein reviewed and discussed might contribute to the development of precision tendon therapies targeting the elderly population.

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腱老化。

肌腱是一种机械敏感的结缔组织，通过传递力量使身体运动，负责连接肌肉和骨骼。然而，随着年龄的增长，肌腱变得更容易退化，随后受伤。肌腱疾病是世界范围内丧失活动能力的主要原因之一，导致肌腱组成、结构和生物力学特性的改变，以及再生潜力的下降。关于肌腱细胞和分子生物学、生物化学和生物力学的相互作用以及肌腱疾病的复杂病理机制的知识仍然非常缺乏。因此，这反映了基础和临床研究的巨大需求，以更好地阐明健康肌腱组织的性质，以及肌腱老化过程和相关疾病。本章简要描述了衰老过程在组织、细胞和分子水平上对肌腱的影响，并简要回顾了肌腱衰老的潜在生物学预测因子。本文回顾和讨论的最新研究结果可能有助于针对老年人的精确肌腱治疗的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sub-cellular biochemistry Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

5.90

自引率

0.00%

发文量

期刊介绍： The book series SUBCELLULAR BIOCHEMISTRY is a renowned and well recognized forum for disseminating advances of emerging topics in Cell Biology and related subjects. All volumes are edited by established scientists and the individual chapters are written by experts on the relevant topic. The individual chapters of each volume are fully citable and indexed in Medline/Pubmed to ensure maximum visibility of the work.