Lifetime changes in body fatness and breast density in postmenopausal women: the FEDRA study.

Giovanna Masala, Benedetta Bendinelli, Saverio Caini, Giacomo Duroni, Ilaria Ermini, Elisa Pastore, Miriam Fontana, Luigi Facchini, Andrea Querci, Maria Antonietta Gilio, Vincenzo Mazzalupo, Melania Assedi, Daniela Ambrogetti, Domenico Palli
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引用次数: 1

Abstract

Background: High mammographic breast density (MBD) is an established risk factor for breast cancer (BC). Body fatness conveys an increased BC risk in postmenopause but is associated with less dense breasts. Here, we studied the relationship between body fatness and breast composition within the FEDRA (Florence-EPIC Digital mammographic density and breast cancer Risk Assessment) longitudinal study.

Methods: Repeated anthropometric data and MBD parameters (obtained through an automated software on BC screening digital mammograms) were available for all participants, as well as information on other BC risk factors. Multivariate linear regression and functional data analysis were used to longitudinally evaluate the association of body fatness, and changes thereof over time, with dense (DV) and non-dense (NDV) breast volumes and volumetric percent density (VPD).

Results: A total of 5,262 women were included, with anthropometric data available at 20 and 40 years of age, at EPIC baseline (mean 49.0 years), and an average of 9.4 years thereafter. The mean number of mammograms per woman was 3.3 (SD 1.6). Body fatness (and increases thereof) at any age was positively associated with DV and NDV (the association being consistently stronger for the latter), and inversely associated with VPD. For instance, an increase by 1 kg/year between the age of 40 years and EPIC baseline was significantly associated with 1.97% higher DV, 8.85% higher NDV, and 5.82% lower VPD.

Conclusion: Body fatness and its increase from young adulthood until midlife are inversely associated with volumetric percent density, but positively associated with dense and non-dense breast volumes in postmenopausal women.

Abstract Image

绝经后妇女体脂和乳腺密度的终生变化:FEDRA研究。
背景:高乳腺密度(MBD)是乳腺癌(BC)的一个确定的危险因素。身体肥胖会增加绝经后乳腺癌的风险,但与乳腺密度较低有关。在这里,我们在FEDRA (Florence-EPIC数字乳房x线摄影密度和乳腺癌风险评估)纵向研究中研究了身体脂肪和乳房成分之间的关系。方法:所有参与者的重复人体测量数据和MBD参数(通过BC筛查数字乳房x线照片上的自动化软件获得),以及其他BC危险因素的信息。采用多元线性回归和功能数据分析来纵向评估体脂及其随时间变化与致密(DV)和非致密(NDV)乳房体积和体积百分比密度(VPD)的关系。结果:共纳入5262名女性,在20岁和40岁、EPIC基线(平均49.0岁)和之后的平均9.4岁时可获得人体测量数据。每位妇女的平均乳房x光检查次数为3.3次(标准差为1.6)。任何年龄的体脂(及其增加)与DV和NDV呈正相关(后者的相关性一贯更强),与VPD呈负相关。例如,在40岁和EPIC基线之间,每增加1 kg/年,DV升高1.97%,NDV升高8.85%,VPD降低5.82%。结论:从青年到中年,体脂及其增加与体积百分比密度呈负相关,但与绝经后妇女致密和非致密乳房体积呈正相关。
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