Ectopic pancreatic acinar cell carcinoma in the thoracic cavity of F344 rat.

IF 0.9 4区医学 Q4 PATHOLOGY

Journal of Toxicologic Pathology Pub Date : 2023-04-01 DOI:10.1293/tox.2022-0114

Chinatsu Fujiwara, Shinya Miyazaki, Yoshitaka Katoh, Tsuyoshi Ito, Aya Koyama, Naofumi Takahashi, Atsushi Shiga, Takanori Harada

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Abstract

Ectopic pancreatic tissue can occasionally cause inflammation, hemorrhage, stenosis, and invagination, similar to normal pancreatic tissue; however, tumorigenesis is rare. This case report describes an ectopically observed pancreatic acinar cell carcinoma in the thoracic cavity of a female Fischer (F344/DuCrlCrlj) rat. Histopathologically, polygonal tumor cells with periodic acid-Schiff-positive cytoplasmic eosinophilic granules showed solid proliferation and infrequently formed acinus-like structures. Immunohistochemically, the tumor cells were positive for cytokeratin, trypsin, and human B-cell leukemia/lymphoma 10, which specifically reacted with pancreatic acinar cells, and negative for vimentin and human α-smooth muscle actin. Ectopic pancreas develops in the submucosa of the gastrointestinal tract; however, there are few reports of its development and neoplasia in the thoracic cavity. To the best of our knowledge, this is the first report of ectopic pancreatic acinar cell carcinoma in the thoracic cavity of a rat.

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F344大鼠胸腔异位胰腺腺泡细胞癌。

异位胰腺组织偶尔会引起炎症、出血、狭窄和内陷，与正常胰腺组织相似;然而，肿瘤发生是罕见的。本病例报告描述了一例异位观察到的雌性Fischer (F344/DuCrlCrlj)大鼠胸腔胰腺腺泡细胞癌。组织病理学上，具有周期性酸性希夫阳性细胞质嗜酸性粒细胞颗粒的多边形肿瘤细胞呈实体增生，并罕见形成腺泡样结构。免疫组化结果显示，肿瘤细胞角蛋白、胰蛋白酶和与胰腺腺泡细胞特异性反应的人b细胞白血病/淋巴瘤10阳性，而波形蛋白和人α-平滑肌肌动蛋白阴性。异位胰腺在胃肠道粘膜下层发育;然而，很少有报道其发展和肿瘤在胸腔。据我们所知，这是大鼠胸腔异位胰腺腺泡细胞癌的首次报道。

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来源期刊

Journal of Toxicologic Pathology PATHOLOGY-TOXICOLOGY

CiteScore

2.10

自引率

16.70%

发文量

审稿时长

>12 weeks

期刊介绍： JTP is a scientific journal that publishes original studies in the field of toxicological pathology and in a wide variety of other related fields. The main scope of the journal is listed below. Administrative Opinions of Policymakers and Regulatory Agencies Adverse Events Carcinogenesis Data of A Predominantly Negative Nature Drug-Induced Hematologic Toxicity Embryological Pathology High Throughput Pathology Historical Data of Experimental Animals Immunohistochemical Analysis Molecular Pathology Nomenclature of Lesions Non-mammal Toxicity Study Result or Lesion Induced by Chemicals of Which Names Hidden on Account of the Authors Technology and Methodology Related to Toxicological Pathology Tumor Pathology; Neoplasia and Hyperplasia Ultrastructural Analysis Use of Animal Models.