Serum Angiotensin-Converting Enzyme Methylation Level and Its Significance in Patients With Comorbid Major Depressive Disorder and Hypertension.

IF 0.8 4区医学 Q4 CLINICAL NEUROLOGY

Clinical Neuropharmacology Pub Date : 2023-04-26 DOI:10.1097/WNF.0000000000000551

Gulibakeranmu Abula, Jinxian Li, Rui Ma, Tin Zhang, Adila Aji, Yi Zhang

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Abstract

Objective: Major depressive disorder (MDD) often coexists with hypertension (HYT). DNA methylation has elicited vital functionality in their development. Angiotensin-converting enzyme (ACE) is a vital enzyme in blood pressure. This study investigated the effect of ACE methylation on depression and HYT severity in patients with comorbid MDD and HYT (MDD + HYT).

Methods: A total of 119 patients (41 men, 78 women, average age: 56.8 ± 9.1 years) with MDD + HYT were enrolled, with 89 healthy subjects (29 men, 60 women, average age: 57.4 ± 9.7 years) were enrolled. The Hamilton Depression Rating Scale-17 and self-rating depression scale scoring scales were used to assess the depression degree of patients, serum ACE methylation level in MDD + HYT patients was measured by means of bisulfite sequencing polymerase chain reaction, with subsequent analysis of the diagnostic efficacy of ACE methylation for MDD + HYT. The independent risk factors for sMDD + HYT were explored.

Results: Serum ACE methylation levels were significantly increased in MDD + HYT patients. The area under the curve of serum ACE methylation level for accurate diagnosis of MDD + HYT was 0.8471, and the cut-off value was 26.9 (sensitivity 83.19%, specificity 73.03%). ACE methylation was an independent risk factor for sMDD + HYT (P = 0.014; odds ratio, 1.071; 95% confidence interval = 1.014-1.131).

Conclusion: The elevated serum ACE methylation level (P < 0.001) in patients with MDD + HYT elicited definite diagnostic values for MDD + HYT, and ACE methylation level was independently correlated with sMDD + HYT (P < 0.05).

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重度抑郁症合并高血压患者血清血管紧张素转换酶甲基化水平及其意义

目的:重度抑郁障碍(MDD)常与高血压(HYT)共存。DNA甲基化在它们的发育过程中引发了至关重要的功能。血管紧张素转换酶(ACE)是控制血压的重要酶。本研究探讨了ACE甲基化对MDD和HYT合并症(MDD + HYT)患者抑郁和HYT严重程度的影响。方法:纳入MDD + HYT患者119例(男性41例，女性78例，平均年龄56.8±9.1岁)，健康受试者89例(男性29例，女性60例，平均年龄57.4±9.7岁)。采用汉密尔顿抑郁评定量表-17和抑郁自评量表评定患者抑郁程度，亚硫酸氢盐测序聚合酶链反应法测定MDD + HYT患者血清ACE甲基化水平，分析ACE甲基化对MDD + HYT的诊断效果。探讨sMDD + HYT的独立危险因素。结果:MDD + HYT患者血清ACE甲基化水平显著升高。血清ACE甲基化水平对MDD + HYT准确诊断的曲线下面积为0.8471，临界值为26.9(敏感性83.19%，特异性73.03%)。ACE甲基化是sMDD + HYT的独立危险因素(P = 0.014;优势比为1.071;95%置信区间= 1.014-1.131)。结论:MDD + HYT患者血清ACE甲基化水平升高(P < 0.001)对MDD + HYT有明确的诊断价值，且ACE甲基化水平与sMDD + HYT独立相关(P < 0.05)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neuropharmacology 医学-临床神经学

CiteScore

1.20

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Neuropharmacology is a peer-reviewed journal devoted to the pharmacology of the nervous system in its broadest sense. Coverage ranges from such basic aspects as mechanisms of action, structure-activity relationships, and drug metabolism and pharmacokinetics, to practical clinical problems such as drug interactions, drug toxicity, and therapy for specific syndromes and symptoms. The journal publishes original articles and brief reports, invited and submitted reviews, and letters to the editor. A regular feature is the Patient Management Series: in-depth case presentations with clinical questions and answers.