Clinical features and prognosis of autosomal dominant polycystic kidney disease with cerebrovascular complications.

IF 1.1 4区医学 Q3 UROLOGY & NEPHROLOGY

Clinical nephrology Pub Date : 2023-05-01 DOI:10.5414/CN110959

Zhe Li, Song Luo, Yang Wang, Yuchao Zhou, Shutian Xu, Ke Zuo, Shijun Li

{"title":"Clinical features and prognosis of autosomal dominant polycystic kidney disease with cerebrovascular complications.","authors":"Zhe Li, Song Luo, Yang Wang, Yuchao Zhou, Shutian Xu, Ke Zuo, Shijun Li","doi":"10.5414/CN110959","DOIUrl":null,"url":null,"abstract":"Objectives: This retrospective study was used to evaluate the clinical and imaging characteristics and the prognosis of autosomal dominant polycystic kidney disease (ADPKD) with cerebrovascular complications.Materials and methods: We retrospectively analyzed 30 patients with ADPKD complicated with intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH), unruptured intracranial aneurysms (UIAs), or Moyamoya disease (MMD) who were admitted to Jinling Hospital from January 2001 to January 2022. We analyzed the clinical manifestations and imaging characteristics of ADPKD patients with cerebrovascular complications and followed up on their long-term outcomes.Results: 30 patients, 17 men and 13 women, with an average age of 47.5 (40.0, 54.0) years were included in this study, including 12 cases of ICH, 12 cases of SAH, 5 cases of UIA, and 1 case of MMD. The 8 patients who died during follow-up had a lower Glasgow Coma Scale (GCS) on admission (p = 0.024) and a significantly higher serum creatinine (p = 0.004) and blood urea nitrogen (p = 0.006) than the 22 patients with long-term survival.Conclusion: Intracranial aneurysms, SAH, and ICH are the most common cerebrovascular diseases in ADPKD. Patients with low GCS score or worse renal function have a poor prognosis, which can lead to disability and even death.","PeriodicalId":10396,"journal":{"name":"Clinical nephrology","volume":"99 5","pages":"237-246"},"PeriodicalIF":1.1000,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical nephrology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5414/CN110959","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}

引用次数: 1

Abstract

Objectives: This retrospective study was used to evaluate the clinical and imaging characteristics and the prognosis of autosomal dominant polycystic kidney disease (ADPKD) with cerebrovascular complications.

Materials and methods: We retrospectively analyzed 30 patients with ADPKD complicated with intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH), unruptured intracranial aneurysms (UIAs), or Moyamoya disease (MMD) who were admitted to Jinling Hospital from January 2001 to January 2022. We analyzed the clinical manifestations and imaging characteristics of ADPKD patients with cerebrovascular complications and followed up on their long-term outcomes.

Results: 30 patients, 17 men and 13 women, with an average age of 47.5 (40.0, 54.0) years were included in this study, including 12 cases of ICH, 12 cases of SAH, 5 cases of UIA, and 1 case of MMD. The 8 patients who died during follow-up had a lower Glasgow Coma Scale (GCS) on admission (p = 0.024) and a significantly higher serum creatinine (p = 0.004) and blood urea nitrogen (p = 0.006) than the 22 patients with long-term survival.

Conclusion: Intracranial aneurysms, SAH, and ICH are the most common cerebrovascular diseases in ADPKD. Patients with low GCS score or worse renal function have a poor prognosis, which can lead to disability and even death.

查看原文本刊更多论文

常染色体显性多囊肾病伴脑血管并发症的临床特点及预后。

目的:回顾性研究常染色体显性多囊肾病(ADPKD)合并脑血管并发症的临床、影像学特点及预后。材料和方法:回顾性分析2001年1月至2022年1月金陵医院收治的30例ADPKD合并脑出血(ICH)、蛛网膜下腔出血(SAH)、未破裂颅内动脉瘤(UIAs)或烟雾病(MMD)患者。分析ADPKD合并脑血管并发症患者的临床表现和影像学特点，并对其远期预后进行随访。结果:本研究纳入患者30例，男17例，女13例，平均年龄47.5(40.0,54.0)岁，其中ICH 12例，SAH 12例，UIA 5例，烟雾病1例。随访期间死亡的8例患者入院时格拉斯哥昏迷评分(GCS)较低(p = 0.024)，血清肌酐(p = 0.004)和尿素氮(p = 0.006)明显高于长期生存的22例患者。结论:颅内动脉瘤、SAH和ICH是ADPKD中最常见的脑血管疾病。GCS评分较低或肾功能较差的患者预后较差，可导致残疾甚至死亡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical nephrology 医学-泌尿学与肾脏学

CiteScore

2.10

自引率

9.10%

发文量

138

审稿时长

4-8 weeks

期刊介绍： Clinical Nephrology appears monthly and publishes manuscripts containing original material with emphasis on the following topics: prophylaxis, pathophysiology, immunology, diagnosis, therapy, experimental approaches and dialysis and transplantation.