NNMT Is an Immune-Related Prognostic Biomarker That Modulates the Tumor Microenvironment in Pan-Cancer.

4区医学 Q3 Medicine

Disease Markers Pub Date : 2023-02-09 eCollection Date: 2023-01-01 DOI:10.1155/2023/9226712

Wenxiu Liu, Meng Zhu, Xiaoming Li, Limian Er, Shengmian Li

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引用次数: 0

Abstract

Emerging evidence has revealed the significant roles of nicotinamide n-methyltransferase (NNMT) in cancer initiation, development, and progression; however, a pan-cancer analysis of NNMT has not been conducted. In this study, we first thoroughly investigated the expression and prognostic significance of NNMT and the relationship between NNMT and the tumor microenvironment using bioinformatic analysis. NNMT was significantly increased and associated with poor prognosis in many common cancers. NNMT expression correlated with the infiltration levels of cancer-associated fibroblasts and macrophages in pan-cancer. Function enrichment analysis discovered that NNMT related to cancer-promoting and immune pathways in various common cancers, such as colon adenocarcinoma, head and neck squamous cell carcinoma, ovarian serous cystadenocarcinoma, and stomach adenocarcinoma. NNMT expression was positively correlated with tumor-associated macrophages (TAMs), especially M2-like TAMs. The results suggest that NNMT might be a new biomarker for immune infiltration and poor prognosis in cancers, providing new direction on therapeutics of cancers.

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NNMT 是一种与免疫相关的预后生物标志物，可调节泛癌症的肿瘤微环境。

越来越多的证据表明，烟酰胺正甲基转移酶（NNMT）在癌症的发生、发展和恶化过程中起着重要作用；然而，目前还没有对NNMT进行过泛癌症分析。在本研究中，我们首先利用生物信息学分析深入研究了 NNMT 的表达和预后意义，以及 NNMT 与肿瘤微环境之间的关系。在许多常见癌症中，NNMT明显增高并与不良预后相关。在泛癌症中，NNMT的表达与癌症相关成纤维细胞和巨噬细胞的浸润水平相关。功能富集分析发现，在结肠腺癌、头颈部鳞状细胞癌、卵巢浆液性囊腺癌和胃腺癌等多种常见癌症中，NNMT与促癌和免疫通路相关。NNMT 的表达与肿瘤相关巨噬细胞（TAMs），尤其是 M2 样 TAMs 呈正相关。结果表明，NNMT可能是癌症免疫浸润和不良预后的新生物标志物，为癌症治疗提供了新方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Disease Markers 医学-病理学

自引率

0.00%

发文量

792

审稿时长

6-12 weeks

期刊介绍： Disease Markers is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the identification of disease markers, the elucidation of their role and mechanism, as well as their application in the prognosis, diagnosis and treatment of diseases.