Copper radical oxidases: galactose oxidase, glyoxal oxidase, and beyond!

IF 5.6 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Jessica K Fong, Harry Brumer
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引用次数: 3

Abstract

The copper radical oxidases (CROs) are an evolutionary and functionally diverse group of enzymes established by the historically significant galactose 6-oxidase and glyoxal oxidase from fungi. Inducted in 2013, CROs now constitute Auxiliary Activity Family 5 (AA5) in the Carbohydrate-Active Enzymes (CAZy) classification. CROs catalyse the two-electron oxidation of their substrates using oxygen as the final electron acceptor and are particularly distinguished by a cross-linked tyrosine-cysteine co-factor that is integral to radical stabilization. Recently, there has been a significant increase in the biochemically and structurally characterized CROs, which has revealed an expanded natural diversity of catalytic activities in the family. This review provides a brief historical introduction to CRO biochemistry and structural biology as a foundation for an update on current advances in CRO enzymology, biotechnology, and biology across kingdoms of life.

铜自由基氧化酶:半乳糖氧化酶、乙二醛氧化酶等!
铜自由基氧化酶(copper radical oxidases, cro)是由真菌中具有历史意义的半乳糖6-氧化酶和乙二醛氧化酶建立的一组进化和功能多样化的酶。cro于2013年引入,目前已被纳入碳水化合物-活性酶(CAZy)分类中的辅助活性家族5 (AA5)。活性氧催化底物的双电子氧化,使用氧作为最后的电子受体,其特别的特点是交联的酪氨酸-半胱氨酸辅助因子是自由基稳定的组成部分。近年来,具有生物化学和结构特征的cro显著增加,这表明该家族催化活性的自然多样性扩大。本文简要介绍了CRO生物化学和结构生物学的历史,为CRO酶学、生物技术和生命领域生物学的最新进展奠定了基础。
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来源期刊
Essays in biochemistry
Essays in biochemistry 生物-生化与分子生物学
CiteScore
10.50
自引率
0.00%
发文量
105
审稿时长
>12 weeks
期刊介绍: Essays in Biochemistry publishes short, digestible reviews from experts highlighting recent key topics in biochemistry and the molecular biosciences. Written to be accessible for those not yet immersed in the subject, each article is an up-to-date, self-contained summary of the topic. Bridging the gap between the latest research and established textbooks, Essays in Biochemistry will tell you what you need to know to begin exploring the field, as each article includes the top take-home messages as summary points. Each issue of the journal is guest edited by a key opinion leader in the area, and whether you are continuing your studies or moving into a new research area, the Journal gives a complete picture in one place. Essays in Biochemistry is proud to publish Understanding Biochemistry, an essential online resource for post-16 students, teachers and undergraduates. Providing up-to-date overviews of key concepts in biochemistry and the molecular biosciences, the Understanding Biochemistry issues of Essays in Biochemistry are published annually in October.
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