Association between antibiotic prophylaxis and adverse perinatal outcomes in premature rupture of membranes.

IF 1.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Revista da Associacao Medica Brasileira Pub Date : 2023-01-01 DOI:10.1590/1806-9282.20211299

Thaísa de Souza Lima, Flávia Mariane Pagani, Carolina Bianchini Borges, Caetano Galvão Petrini, Marina Carvalho Paschoini, Edward Araújo Júnior, Alberto Borges Peixoto

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引用次数: 0

Abstract

Objective: The aim of this study was to evaluate the association between antibiotic prophylaxis and adverse perinatal outcomes in premature rupture of membranes.

Methods: This retrospective cohort included pregnant women with premature rupture of membranes (between 24 and 33+6 weeks) who used or did not use prophylactic antibiotics. Pearson's chi-square (χ²) test, Student's t-test, and binary logistic regression were used for statistical analysis.

Results: A significant effect was observed in patients with premature rupture of membranes using prophylactic antibiotics regarding amniotic fluid index (p=0.007), deepest vertical pocket (p=0.049), duration of antibiotic therapy (p≤0.001), C-reactive protein level upon admission (p≤0.001), leukocyte count upon admission (p=0.007), and length of stay in neonatal intensive care (p=0.047). A significant association was observed between the abovementioned patients and surfactant use during the neonatal period (p=0.04). A higher prevalence of surfactant use was noted in these patients (20.0 vs. 8.7%; p=0.04).

Conclusion: No association was found between antibiotic prophylaxis and the presence of adverse perinatal outcomes in pregnant women with premature rupture of membranes between 24 and 33+6 weeks of gestation.

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抗生素预防与胎膜早破不良围产期结局之间的关系。

目的:本研究的目的是评估抗生素预防与胎膜早破不良围产期结局之间的关系。方法:该回顾性队列包括使用或未使用预防性抗生素的胎膜早破孕妇(24 ~ 33+6周)。采用Pearson χ 2检验、Student’st检验和二元logistic回归进行统计分析。结果:预防性抗生素对早破羊水指数(p=0.007)、最深垂直袋(p=0.049)、抗生素治疗时间(p≤0.001)、入院时c反应蛋白水平(p≤0.001)、入院时白细胞计数(p=0.007)、新生儿重症监护时间(p=0.047)均有显著影响。上述患者与新生儿期表面活性剂的使用有显著相关性(p=0.04)。这些患者使用表面活性剂的比例较高(20.0% vs. 8.7%;p = 0.04)。结论:在妊娠24 ~ 33+6周的胎膜早破孕妇中，抗生素预防与不良围产期结局无关联。

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来源期刊

Revista da Associacao Medica Brasileira 医学-医学：内科

CiteScore

2.20

自引率

0.00%

发文量

276

审稿时长

12 weeks

期刊介绍： A Revista da Associação Médica Brasileira (RAMB), editada pela Associação Médica Brasileira, desde 1954, tem por objetivo publicar artigos que contribuam para o conhecimento médico.