Blood Biomarkers in Brain Injury Medicine.

IF 1 Q4 REHABILITATION

Current Physical Medicine and Rehabilitation Reports Pub Date : 2022-02-26 DOI:10.1007/s40141-022-00343-w

William R McBride, Caroline E Conlan, Nicole A Barylski, Amelie C Warneryd, Randel L Swanson

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引用次数: 3

Abstract

Purpose of review: This review seeks to explore blood-based biomarkers with the potential for clinical implementation.

Recent findings: Emerging non-proteomic biomarkers hold promise for more accurate diagnostic and prognostic capabilities, especially in the subacute to chronic phase of TBI recovery. Further, there is a growing understanding of the overlap between TBI-related and Dementia-related blood biomarkers.

Summary: Given the significant heterogeneity inherent in the clinical diagnosis of Traumatic Brain Injury (TBI), there has been an exponential increase in TBI-related biomarker research over the past two decades. While TBI-related biomarker assessments include both cerebrospinal fluid analysis and advanced neuroimaging modalities, blood-based biomarkers hold the most promise to be non-invasive biomarkers widely available to Brain Injury Medicine clinicians in diverse practice settings. In this article, we review the most relevant blood biomarkers for the field of Brain Injury Medicine, including both proteomic and non-proteomic blood biomarkers, biomarkers of cerebral microvascular injury, and biomarkers that overlap between TBI and Dementia.

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脑损伤医学中的血液生物标志物。

综述目的:本综述旨在探索具有临床应用潜力的血液生物标志物。最新发现:新兴的非蛋白质组生物标志物有望提供更准确的诊断和预后能力，特别是在TBI恢复的亚急性到慢性期。此外，人们对创伤性脑损伤相关和痴呆症相关的血液生物标志物之间的重叠有了越来越多的了解。摘要:由于创伤性脑损伤(TBI)的临床诊断具有显著的异质性，在过去的二十年中，与TBI相关的生物标志物研究呈指数级增长。虽然tbi相关的生物标志物评估包括脑脊液分析和先进的神经成像模式，但基于血液的生物标志物最有希望成为非侵入性生物标志物，广泛应用于各种实践环境中的脑损伤医学临床医生。在本文中，我们回顾了与脑损伤医学领域最相关的血液生物标志物，包括蛋白质组学和非蛋白质组学血液生物标志物，脑微血管损伤生物标志物，以及TBI和痴呆之间重叠的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Physical Medicine and Rehabilitation Reports Medicine-Rehabilitation

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： This journal aims to offer expert review articles on the most significant recent developments in physical medicine and rehabilitation. By providing clear, insightful, balanced contributions, the journal serves those for whom an understanding of emerging knowledge in the rehabilitation sciences is essential to optimizing health, function, and participation in individuals with physical disabilities. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An Editorial Board of more than 20 internationally diverse members reviews the annual table of contents, ensures that topics include emerging research, and suggests topics of special importance to their country/region. Topics covered may include amputee rehabilitation; interventional pain management; musculoskeletal rehabilitation; pediatric rehabilitation; spinal cord injury rehabilitation; stroke rehabilitation; swallowing disorders; and traumatic brain injury rehabilitation.