The effects of epigenetic modifications on bone remodeling in age-related osteoporosis.

IF 2.8 4区医学 Q3 CELL BIOLOGY

Connective Tissue Research Pub Date : 2023-03-01 DOI:10.1080/03008207.2022.2120392

Wenyue Yu, He-Ling Wang, Jianying Zhang, Chengcheng Yin

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引用次数: 1

Abstract

Purpose: As the population ages, there is an increased risk of fracture and morbidity diseases associated with aging, such as age-related osteoporosis and other bone diseases linked to aging skeletons.

Results: Several bone-related cells, including multipotent bone mesenchymal stem cells, osteoblasts that form bone tissue, and osteoclasts that break it down, are in symbiotic relationships throughout life. Growing evidence indicates that epigenetic modifications of cells caused by aging contribute to compromised bone remodeling and lead to osteoporosis. A number of epigenetic mechanisms are at play, including DNA/RNA modifications, histone modifications, microRNAs (miRNAs), and long noncoding RNAs (lncRNAs), as well as chromatin remodeling.

Conclusion: In this review, we summarized the epigenetic modifications of different bone-related cells during the development and progression of osteoporosis associated with aging. Additionally, we described a compensatory recovery mechanism under epigenetic regulation that may lead to new strategies for regulating bone remodeling in age-related osteoporosis.

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表观遗传修饰对年龄相关性骨质疏松症骨重塑的影响。

目的:随着人口老龄化，与衰老相关的骨折和发病率疾病的风险增加，如与年龄相关的骨质疏松症和其他与骨骼老化有关的骨骼疾病。结果:几种骨相关细胞，包括多能骨间充质干细胞、形成骨组织的成骨细胞和分解骨组织的破骨细胞，在一生中都处于共生关系。越来越多的证据表明，由衰老引起的细胞表观遗传修饰有助于骨骼重塑受损并导致骨质疏松症。许多表观遗传机制起作用，包括DNA/RNA修饰，组蛋白修饰，microRNAs (miRNAs)，长链非编码RNA (lncRNAs)，以及染色质重塑。结论:本文综述了衰老相关骨质疏松发生发展过程中不同骨相关细胞的表观遗传修饰。此外，我们描述了表观遗传调控下的代偿恢复机制，这可能导致调节年龄相关性骨质疏松症骨重塑的新策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Connective Tissue Research 生物-细胞生物学

CiteScore

6.60

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： The aim of Connective Tissue Research is to present original and significant research in all basic areas of connective tissue and matrix biology. The journal also provides topical reviews and, on occasion, the proceedings of conferences in areas of special interest at which original work is presented. The journal supports an interdisciplinary approach; we present a variety of perspectives from different disciplines, including Biochemistry Cell and Molecular Biology Immunology Structural Biology Biophysics Biomechanics Regenerative Medicine The interests of the Editorial Board are to understand, mechanistically, the structure-function relationships in connective tissue extracellular matrix, and its associated cells, through interpretation of sophisticated experimentation using state-of-the-art technologies that include molecular genetics, imaging, immunology, biomechanics and tissue engineering.