BIOMAGNETISM OF DRUG-SENSITIVE AND DRUG-RESISTANT MALIGNANT TUMORS AFTER INJECTION OF FERROMAGNETIC NANOCOMPOSITE.

Q3 Medicine

Experimental oncology Pub Date : 2022-12-01 DOI:10.32471/exp-oncology.2312-8852.vol-44-no-4.19093

I N Todor, N Yu Lukianova, M A Primin, I V Nedayvoda, V F Chekhun

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Abstract

Magnetic signals emitted by living organisms, regardless of a biological species, are important biophysical indicators. The study of these indicators is very relevant and promising for the visualization of the tumor process and the development of technologies using artificial intelligence when it comes to malignant neoplasms, particularly resistant to chemotherapy.

Aim: To measure magnetic signals from transplantable rat tumors and their counterparts resistant to cytostatics for evaluating the features of the accumulation of iron-containing nanocomposite Ferroplat.

Materials and methods: Doxorubicin (Dox)-sensitive and Dox-resistant Walker-256 carcinosarcoma and cisplatin-sensitive and cisplatin-resistant Guerin's carcinoma transplanted in female Wistar rats were studied. The magnetism of tumors, liver and heart was determined using Superconductive Quantum Interference Device (SQUID) - magnetometry in a non-contact (13 mm over the tumor) way using specially designed computer programs. In a group of the experimental animals, a ferromagnetic nanocomposite (Ferroplat) was administered as a single intravenous injection and biomagnetism was assessed in 1 h.

Results: The magnetic signals coming from Dox-resistant Walker-256 carcinosarcoma in the exponential growth phase were significantly higher in comparison with sensitive tumor. Intravenous administration of Ferroplat increased biomagnetism by at least an order of magnitude, especially in resistant tumors. At the same time, the magnetic signals of the liver and heart were within the magnetic noise.

Conclusion: The use of SQUID-magnetometry with ferromagnetic nanoparticles as a contrast agent is a promising approach for visualization of malignant neoplasms with varying sensitivity to chemotherapy.

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铁磁纳米复合材料注射后对药物敏感和耐药恶性肿瘤的生物磁学研究。

无论是何种生物，生物体发出的磁信号都是重要的生物物理指标。这些指标的研究对于肿瘤过程的可视化和利用人工智能技术开发恶性肿瘤，特别是对化疗有耐药性的肿瘤，具有非常重要的意义和前景。目的:测定可移植大鼠肿瘤及其耐细胞抑制剂对应肿瘤的磁信号，以评价含铁纳米复合材料铁板的蓄积特性。材料与方法:对雌性Wistar大鼠移植的多柔比星(Dox)敏感和耐药的Walker-256癌肉瘤和顺铂敏感和耐药的Guerin癌进行研究。利用专门设计的计算机程序，采用超导量子干涉装置(SQUID) -非接触式(距肿瘤13mm)磁强计来测定肿瘤、肝脏和心脏的磁性。在一组实验动物中，单次静脉注射铁磁纳米复合材料(Ferroplat)，并在1 h内评估生物磁学。结果:与敏感肿瘤相比，Dox-resistant Walker-256癌肉瘤指数生长期的磁信号明显更高。静脉注射铁铂至少增加了一个数量级的生物磁性，特别是在耐药肿瘤中。同时，肝脏和心脏的磁信号在磁噪声范围内。结论:使用squid磁强计与铁磁纳米颗粒作为对比剂，是一种很有前途的方法来显示对化疗敏感性不同的恶性肿瘤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental oncology Medicine-Oncology

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The Experimental Oncology is an English-language journal that publishes review articles, original contributions, short communications, case reports and technical advances presenting new data in the field of experimental and fundamental oncology. Manuscripts should be written in English, contain original work, which has not been published or submitted for publication elsewhere. It also implies the transfer of the Copyright from the author to “Experimental Oncology”. No part of journal publications may be reproduced, stored in a retrieval system or transmitted in any form or by any means without the prior permission of the publisher.