Effects of Modafinil (Provigil) on Memory and Learning in Experimental and Clinical Studies: From Molecular Mechanisms to Behaviour Molecular Mechanisms and Behavioural Effects.

IF 2.4 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current molecular pharmacology Pub Date : 2023-01-01 DOI:10.2174/1874467215666220901122824

Mohammad Yassin Zamanian, Mahdi Najafiani Karimvandi, Marjan Nikbakhtzadeh, Elham Zahedi, Dmitry Olegovich Bokov, Małgorzata Kujawska, Mahsa Heidari, Mohammad Reza Rahmani

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引用次数: 0

Abstract

Modafinil (MOD, 2-diphenyl-methyl-sulphinil-2-acetamide) is a stimulant-like medicine used to treat narcolepsy. Off-label uses include improving cognitive ability in the course of other diseases. This review aims to discuss findings demonstrating the memory and learningenhancing activity of MOD in experimental and clinical studies. We included behavioral evaluations alongside the effects of MOD at the cellular and molecular level. MOD in different animal disease models exerted beneficial effects on induced memory and learning impairment, which in some cases were accompanied by modulation of neurotransmitter pathways or neuroplastic capabilities, reducing oxidative stress, or expression of synaptic proteins. Individuals treated with MOD showed improved memory and learning skills in different conditions. These effects were associated with regulating brain activity in some participants, confirmed by functional magnetic resonance imaging. Presented herein, data support the use of MOD in treating memory and learning deficits in various disease conditions.

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莫达非尼(Provigil)在实验和临床研究中对记忆和学习的影响:从分子机制到行为。

莫达非尼(MOD, 2-二苯基-甲基-磺胺-2-乙酰胺)是一种类似兴奋剂的药物，用于治疗嗜睡症。说明书外用途包括改善其他疾病过程中的认知能力。本文就MOD对记忆和学习的促进作用在实验和临床研究中的发现进行综述。我们将行为评估与MOD在细胞和分子水平上的影响结合起来。MOD在不同动物疾病模型中对诱导记忆和学习障碍有有益的影响，在某些情况下，这伴随着神经递质通路或神经可塑性的调节，减少氧化应激或突触蛋白的表达。接受MOD治疗的个体在不同条件下表现出更好的记忆和学习技能。这些影响与调节一些参与者的大脑活动有关，功能性磁共振成像证实了这一点。在此，数据支持使用MOD治疗记忆和学习缺陷在各种疾病条件下。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current molecular pharmacology Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

4.90

自引率

3.70%

发文量

112

期刊介绍： Current Molecular Pharmacology aims to publish the latest developments in cellular and molecular pharmacology with a major emphasis on the mechanism of action of novel drugs under development, innovative pharmacological technologies, cell signaling, transduction pathway analysis, genomics, proteomics, and metabonomics applications to drug action. An additional focus will be the way in which normal biological function is illuminated by knowledge of the action of drugs at the cellular and molecular level. The journal publishes full-length/mini reviews, original research articles and thematic issues on molecular pharmacology. Current Molecular Pharmacology is an essential journal for every scientist who is involved in drug design and discovery, target identification, target validation, preclinical and clinical development of drugs therapeutically useful in human disease.