Personal air pollution exposure and metals in the nasal epithelial lining fluid of COPD patients.

Environmental research, health : ERH Pub Date : 2023-06-01 Epub Date: 2023-03-01 DOI:10.1088/2752-5309/acbbe5
Hilary L Zetlen, Anna Stanley Lee, Lina Nurhussien, Wendy Sun, Choong-Min Kang, Antonella Zanobetti, Mary B Rice
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Abstract

Sampling of the nasal epithelial lining fluid is a potential method to assess exposure to air pollution within the respiratory tract among high risk populations. We investigated associations of short- and long-term particulate matter exposure (PM) and pollution-related metals in the nasal fluid of people with chronic obstructive pulmonary disease (COPD). This study included 20 participants with moderate-to-severe COPD from a larger study who measured long-term personal exposure to PM2.5 using portable air monitors and short-term PM2.5 and black carbon (BC) using in-home samplers for the seven days preceding nasal fluid collection. Nasal fluid was sampled from both nares by nasosorption, and inductively coupled plasma mass spectrometry was used to determine the concentration of metals with major airborne sources. Correlations of selected elements (Fe, Ba, Ni, Pb, V, Zn, Cu) were determined within the nasal fluid. Associations between personal long-term PM2.5 and seven day home PM2.5 and BC exposure and nasal fluid metal concentrations were determined by linear regression. Within nasal fluid samples, concentrations of vanadium and nickel (r = 0.8) and lead and zinc (r = 0.7) were correlated. Seven day and long-term PM2.5 exposure were both associated with higher levels of copper, lead, and vanadium in the nasal fluid. BC exposure was associated with higher levels of nickel in the nasal fluid. Levels of certain metals in the nasal fluid may serve as biomarkers of air pollution exposure in the upper respiratory tract.

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慢性阻塞性肺病患者个人空气污染暴露与鼻上皮内液中的金属
鼻腔上皮衬里液取样是评估高危人群呼吸道内空气污染暴露情况的一种潜在方法。我们调查了慢性阻塞性肺病(COPD)患者鼻液中短期和长期颗粒物暴露(PM)与污染相关金属的关系。这项研究包括20名来自一项大型研究的中重度COPD参与者,他们使用便携式空气监测仪测量了个人长期接触PM2.5的情况,并使用家庭采样器测量了在鼻液采集前七天的短期PM2.5和黑碳(BC)。通过鼻吸附法从两个鼻孔取样,并使用电感耦合等离子体质谱法测定主要空气来源的金属浓度。在鼻液中测定所选元素(Fe、Ba、Ni、Pb、V、Zn、Cu)的相关性。通过线性回归确定个人长期PM2.5和七天家庭PM2.5、BC暴露和鼻腔液体金属浓度之间的相关性。在鼻液样本中,钒和镍的浓度(r=0.8)以及铅和锌的浓度(r=0.7)是相关的。七天和长期接触PM2.5都与鼻腔中铜、铅和钒含量较高有关。BC暴露与鼻液中镍含量较高有关。鼻腔液体中某些金属的水平可以作为上呼吸道空气污染暴露的生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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