[Reference intervals of thyroidstimulating hormone in pregnant women living in the central regions of the Russian Federation].

Q4 Medicine
A A Rybakova, N M Platonov, N M Malysheva, L V Nikankina, A R Elfimova, E A Troshina
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Abstract

Background: Pregnancy is a condition with important structural and physiological changes in the thyroid gland. In this regard, experts of thyroid associations have recommended developing specific reference intervals taking into account the natural and socio-geographical characteristics of the region under study.

Aim: To conduct an epidemiological analysis and evaluate TSH reference intervals in pregnant women living in the central regions of the Russian Federation with mild iodine deficiency.

Materials and methods: We have conducted the observational multicenter cross-sectional study included 2008 healthy pregnant women at different trimesters of pregnancy, from three regions of the Russian Federation (Moscow, Ivanovo and Smolensk). We assessed the level of thyroid-stimulating hormone, antibodies to thyroid peroxidase, antibodies to serum thyroglobulin, the level of iodine concentration in the morning portion of urine (cerium arsenic method) and we have conducted a questionnaire (date birth and gestational age). Women with elevated titers of anti-TPO and/or anti-TG antibodies were excluded from the study (245 women). As a result, we assessed high and medium levels of TSH and its overestimation with iodine sufficiency in pregnant women. The results are presented using the calculation of 2.5 and 97.5 percentiles.

Results: We confirmed the presence of iodine deficiency in the study areas. The median concentration of iodine in the urine was: in Moscow 106 μg/l, in Ivanovo 119 μg/l, in Smolensk 134 μg/l. Pregnant women were divided into 2 groups according to iodine adequacy. In the group with optimal iodine supply, the level of TSH was 0,006-3,36 in the 1st trimester, 0,20-3,74 in the 2nd trimester, and 0,33-3,68 mIU/L in the 3rd trimester. In the group with mild iodine deficiency - in the 1st trimester it was 0,11-3,00, in the 2nd trimester 0,22-3,78, in the 3rd trimester 0,07-3,04 mIU/l. Statistical analysis of the data revealed that when comparing the level of TSH by trimester, depending on the place of residence, no statistical difference was found (p = 0,239).

Conclusion: We obtained that the level of TSH in healthy pregnant women living in the central regions of the Russian Federation does not exceed 3.8 mIU/l in all trimesters.

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[俄罗斯联邦中部地区孕妇促甲状腺激素的参考区间]。
背景:妊娠是甲状腺发生重要结构和生理变化的一种情况。在这方面,甲状腺协会的专家建议,考虑到所研究区域的自然和社会地理特征,制定具体的参考间隔。目的:对俄罗斯联邦中部地区轻度碘缺乏症孕妇的TSH参考区间进行流行病学分析和评价。材料和方法:我们对来自俄罗斯联邦三个地区(莫斯科、伊万诺沃和斯摩棱斯克)的2008名处于不同妊娠期的健康孕妇进行了多中心横断面观察研究。我们评估了促甲状腺激素水平、甲状腺过氧化物酶抗体水平、血清甲状腺球蛋白抗体水平、晨尿碘浓度水平(砷铈法),并进行了问卷调查(出生日期和胎龄)。抗tpo和/或抗tg抗体滴度升高的妇女被排除在研究之外(245名妇女)。因此,我们评估了孕妇高和中等水平的TSH及其与碘充足的高估。结果采用2.5和97.5百分位计算。结果:证实研究地区存在碘缺乏症。尿碘中位数浓度为:莫斯科106 μg/l,伊万诺沃119 μg/l,斯摩棱斯克134 μg/l。根据碘的充足性将孕妇分为两组。最佳碘供应组妊娠早期TSH水平为0.006 -3,36,妊娠中期为0.20 -3,74,妊娠晚期为0.33 -3,68 mIU/L。在轻度缺碘组中,孕早期为0.11 -3 000,孕中期为0.22 -3,78,孕晚期为0.07 -3,04 mIU/l。对数据进行统计分析后发现,不同居住地不同孕期的TSH水平比较,差异无统计学意义(p = 0,239)。结论:生活在俄罗斯联邦中部地区的健康孕妇在所有妊娠期TSH水平不超过3.8 mIU/l。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Problemy endokrinologii
Problemy endokrinologii Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
1.40
自引率
0.00%
发文量
59
期刊介绍: Since 1955 the “Problems of Endocrinology” (or “Problemy Endocrinologii”) Journal publishes timely articles, balancing both clinical and experimental research, case reports, reviews and lectures on pressing problems of endocrinology. The Journal is aimed to the most topical issues of endocrinology: to chemical structure, biosynthesis and metabolism of hormones, the mechanism of their action at cellular and molecular level; pathogenesis and to clinic of the endocrine diseases, new methods of their diagnostics and treatment. The Journal: features original national and foreign research articles, reflecting world endocrinology development; issues thematic editions on specific areas; publishes chronicle of major international congress sessions and workshops on endocrinology, as well as state-of-the-art guidelines; is intended for scientists, endocrinologists diabetologists and specialists of allied trade, general practitioners, family physicians and pediatrics.
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