Prognostic value of KI-67 proliferation index in luminal breast cancers.

IF 0.5 4区医学 Q4 SURGERY

Cirugia Y Cirujanos Pub Date : 2023-01-01 DOI:10.24875/CIRU.22000043

Şeref Dokcu, Mehmet Ali-Çaparlar, Özhan Çetindağ, Musluh Hakseven, Aydan Eroğlu

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引用次数: 0

Abstract

Aim: This study aimed to examine the prognostic significance of the KI-67 proliferation index, especially in breast cancer (BC) patients without HER-2 expression and no nodal involvement.

Material and methods: The database of hormone-receptor-positive patients who underwent surgery for BC in our Surgical Oncology Clinic between 2008 and 2020 was retrospectively reviewed and recorded. Patients were categorized based on their KI-67 level, considering the cutoff value of 20%.

Results: Our study revealed that tumors with high KI-67 levels were more likely to have a more advanced histological grade (p = 0.00) and size (p = 0.038). In the univariant analysis, KI-67 level was effective on overall survival (p = 0.044) and disease-free survival (p = 0.048). However, we found that there was no independent prognostic factor in the multivariant analysis.

Conclusion: Although the Ki-67 proliferation index does not yet have an agreed threshold value and scoring methodology, it can also be used to determine prognosis and evaluate treatment response in some patients.

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KI-67增殖指数在腔内乳腺癌中的预后价值。

目的:本研究旨在探讨KI-67增殖指数在无HER-2表达和无淋巴结累及的乳腺癌(BC)患者中的预后意义。材料和方法:回顾性回顾和记录2008年至2020年在我院外科肿瘤诊所接受BC手术的激素受体阳性患者数据库。根据KI-67水平，考虑20%的临界值对患者进行分类。结果:我们的研究显示，KI-67水平高的肿瘤更有可能具有更高的组织学分级(p = 0.00)和更大的肿瘤(p = 0.038)。在单变量分析中，KI-67水平对总生存期(p = 0.044)和无病生存期(p = 0.048)有效。然而，我们发现在多变量分析中没有独立的预后因素。结论:虽然Ki-67增殖指数尚未有统一的阈值和评分方法，但在部分患者中，Ki-67增殖指数也可用于判断预后和评价治疗反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cirugia Y Cirujanos 医学-外科

CiteScore

0.90

自引率

20.00%

发文量

207

审稿时长

6-12 weeks

期刊介绍： Cirugía y Cirujanoses exponente del desarrollo académico, científico, médico, quirúrgico y tecnológico en materia de salud en México y en el ámbito internacional. Es una revista bimestral, open access, revisada por pares, que publica en español y en inglés (traducido sin coste para los autores) artículos científicos originales, casos clínicos, artículos de revisión de interés general y cartas al editor. Los artículos se seleccionan y publican siguiendo un riguroso análisis, de acuerdo con los estándares internacionalmente aceptados. Sus espacios están abiertos a los académicos, así como a todo miembro de la comunidad médica que manifieste interés por utilizar este foro para publicar sus trabajos.