Total Fluid Administration and Weight Loss during the First 2 Weeks in Infants Randomized to Early Enteral Feeding after Extremely Preterm Birth.

IF 2.6 3区医学 Q1 PEDIATRICS

Neonatology Pub Date : 2023-01-01 Epub Date: 2022-11-28 DOI:10.1159/000527430

Leandra Durham, Emily Gunawan, Kelly Nguyen, Audrey Reeves, Vivek Shukla, Ariel A Salas

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引用次数: 0

Abstract

Background: Randomized trials have not reported the effects of the early progression of feeding volumes on fluid balance and neurodevelopment among infants born extremely preterm (≤28 weeks).

Method: Fluid, electrolyte, and neurodevelopment data of 60 extremely preterm infants randomly assigned to receive either 1 (early feeding group) or 4 days (late feeding group) of trophic feeding volumes at 20-24 mL/kg/day were analyzed.

Results: Infants randomized to the early feeding group received less parenteral fluids, generated lower urine volumes, and had less excessive weight loss during the first 14 days after birth. The 7-point difference in cognitive scores and the 0.5 difference in weight-for-age z-scores favoring the early feeding group did not reach statistical significance.

Conclusions: In extremely preterm infants, early enteral feeding is associated with less total fluid administration and with less excessive weight loss during the first 2 weeks after birth. These short-term effects could have long-lasting benefits.

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极度早产后随机接受早期肠内喂养的婴儿头两周的总输液量和体重减轻。

背景：随机试验尚未报告早期逐渐增加喂养量对极早产儿（≤28 周）体液平衡和神经发育的影响：方法：对随机分配到接受1天（早期喂养组）或4天（晚期喂养组）20-24毫升/千克/天营养喂养的60名极度早产儿的体液、电解质和神经发育数据进行分析：结果：被随机分配到早期喂养组的婴儿在出生后的前 14 天内接受的肠外输液较少，尿量较少，体重过度减轻的情况也较少。早期喂养组婴儿的认知评分相差 7 分，体重与年龄 Z 值相差 0.5 分，但这两项数据均未达到统计学意义：在极早产儿中，早期肠内喂养与减少总液体用量和减少出生后两周内体重过度下降有关。这些短期效果可能会带来长期益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neonatology 医学-小儿科

CiteScore

0.60

自引率

4.00%

发文量

审稿时长

6-12 weeks

期刊介绍： This highly respected and frequently cited journal is a prime source of information in the area of fetal and neonatal research. Original papers present research on all aspects of neonatology, fetal medicine and developmental biology. These papers encompass both basic science and clinical research including randomized trials, observational studies and epidemiology. Basic science research covers molecular biology, molecular genetics, physiology, biochemistry and pharmacology in fetal and neonatal life. In addition to the classic features the journal accepts papers for the sections Research Briefings and Sources of Neonatal Medicine (historical pieces). Papers reporting results of animal studies should be based upon hypotheses that relate to developmental processes or disorders in the human fetus or neonate.