Effects of Intensive Versus Distributed Constraint-Induced Movement Therapy for Children With Unilateral Cerebral Palsy: A Quasi-Randomized Trial.

IF 3.7 2区医学 Q1 CLINICAL NEUROLOGY

Neurorehabilitation and Neural Repair Pub Date : 2023-02-01 DOI:10.1177/15459683231162330

Tien-Ni Wang, Kai-Jie Liang, Yi-Chia Liu, Jeng-Yi Shieh, Hao-Ling Chen

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引用次数: 0

Abstract

Background: Previous studies have compared the effectiveness of constraint-induced movement therapy (CIMT) by different training doses. However, whether the dosing schedule, that is, intensive or distributed, influences the effectiveness of CIMT in children with unilateral cerebral palsy (CP) is unknown.

Objective: To investigate the effectiveness of intensive and distributed CIMT for children with unilateral CP.

Methods: Fifty children with unilateral CP were assigned to intensive or distributed CIMT group with a total of 36 training hours. The intensive CIMT was delivered within 1 week, and the distributed CIMT was delivered twice a week for 8 weeks. The outcomes were the Melbourne Assessment 2, Box and Block Test, Pediatric Motor Activity Log-Revised (PMAL-R), Bruininks-Oseretsky test of motor proficiency 2, ABILHAND-Kids and Parenting Stress Index-Short Form. The intensive group was assessed at the initiation of treatment (week 0), at the end of 1 week treatment (week 1), and 8 weeks after the initiation of treatment (week 8). The distributed group was assessed at week 0 and week 8.

Results: The within-group analyses demonstrated significant differences on all motor outcomes. There were no significant between-group differences at post-treatment, while the intensive CIMT demonstrated larger improvements than the distributed CIMT did on quality of use of the more-affected hand, as rated by parents on the PMAL-R at week 8.

Conclusions: The 2 dosing schedules of CIMT had similar effectiveness for children with unilateral CP. The intensive CIMT yielded additional improvement on parent rated motor quality of the more-affected hand at 8 weeks after the initiation of treatment.

Trial registration: ClinicalTrials.gov (ID: NCT03128385).

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强化与分布式约束诱导运动治疗对单侧脑瘫儿童的影响:一项准随机试验。

背景:以往的研究比较了不同训练剂量的约束诱导运动疗法(CIMT)的效果。然而，剂量计划，即密集或分布，是否影响CIMT在单侧脑瘫(CP)儿童中的有效性尚不清楚。目的:探讨强化和分布式CIMT治疗单侧CP患儿的效果。方法:将50例单侧CP患儿分为强化和分布式CIMT组，共36学时。集约型CIMT在1周内进行，分布式CIMT每周进行2次，持续8周。结果包括墨尔本评估2、盒块测验、儿童运动活动记录修正(PMAL-R)、Bruininks-Oseretsky运动能力测验2、ABILHAND-Kids和父母压力指数简表。强化组在治疗开始(第0周)、治疗1周结束(第1周)和治疗开始后8周(第8周)进行评估。分布式组在第0周和第8周进行评估。结果:组内分析显示所有运动结果均有显著差异。治疗后各组间无显著差异，而在第8周父母对PMAL-R的评价中，强化CIMT比分布式CIMT在受影响更大的手的使用质量方面表现出更大的改善。结论:CIMT的两种给药方案对单侧CP的儿童具有相似的效果。强化CIMT在治疗开始后8周对受影响更大的手的父母评价的运动质量有额外的改善。试验注册:ClinicalTrials.gov (ID: NCT03128385)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurorehabilitation and Neural Repair 医学-康复医学

CiteScore

8.30

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Neurorehabilitation & Neural Repair (NNR) offers innovative and reliable reports relevant to functional recovery from neural injury and long term neurologic care. The journal''s unique focus is evidence-based basic and clinical practice and research. NNR deals with the management and fundamental mechanisms of functional recovery from conditions such as stroke, multiple sclerosis, Alzheimer''s disease, brain and spinal cord injuries, and peripheral nerve injuries.