Unexpected Effects of Cerebrospinal Fluid on the Prevention of Cerebral Thromboembolism and Blood-Brain Barrier Disruption: First Experimental Study.

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL

Eurasian Journal of Medicine Pub Date : 2023-02-01 DOI:10.5152/eurasianjmed.2023.22317

Mete Zeynal

{"title":"Unexpected Effects of Cerebrospinal Fluid on the Prevention of Cerebral Thromboembolism and Blood-Brain Barrier Disruption: First Experimental Study.","authors":"Mete Zeynal","doi":"10.5152/eurasianjmed.2023.22317","DOIUrl":null,"url":null,"abstract":"Objective: We investigated the presence of thromboembolism that may develop in hippocampal arteries due to decreased cerebrospinal fluid volume because of choroid plexus damage caused by subarachnoid hemorrhage.Materials and methods: Twenty-four rabbits were included as test subjects in this study. The study group comprised 14 test subjects administered autologous blood (0.5 mL). Coronary sections of the temporal uncus were prepared to observe the choroid plexus and the hippocampus together. Cellular shrinkage, darkening, halo formation, and ciliary element loss were considered criteria for degeneration. Blood-brain barriers were also examined in the hippocampus. The density of degenerated epithelial cells in the choroid plexus (n/mm3 ) and thromboembolisms in the hippocampal arteries (n/cm2 ) were compared statistically.Results: Histopathological examination revealed that the number of degenerated epithelial cells in the choroid plexus and the number of thromboembolisms in the hippocampal arteries were 7 ± 2 and 1 ± 1 in group 1, 16 ± 4 and 3 ± 1 in group 2, and 64 ± 9 and 6 ± 2 in group 3, respectively. The significance levels were P < .005 for group 1 vs. group 2, P < .0005 for group 2 vs. group 3, and P < .00001 for group 1 vs. group 3.Conclusion: This study demonstrates that decreased cerebrospinal fluid volume induced by choroid plexus degeneration causes cerebral thromboembolism following subarachnoid hemorrhage, which has not been previously described.","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.9000,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10081128/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eurasian Journal of Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5152/eurasianjmed.2023.22317","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: We investigated the presence of thromboembolism that may develop in hippocampal arteries due to decreased cerebrospinal fluid volume because of choroid plexus damage caused by subarachnoid hemorrhage.

Materials and methods: Twenty-four rabbits were included as test subjects in this study. The study group comprised 14 test subjects administered autologous blood (0.5 mL). Coronary sections of the temporal uncus were prepared to observe the choroid plexus and the hippocampus together. Cellular shrinkage, darkening, halo formation, and ciliary element loss were considered criteria for degeneration. Blood-brain barriers were also examined in the hippocampus. The density of degenerated epithelial cells in the choroid plexus (n/mm3 ) and thromboembolisms in the hippocampal arteries (n/cm2 ) were compared statistically.

Results: Histopathological examination revealed that the number of degenerated epithelial cells in the choroid plexus and the number of thromboembolisms in the hippocampal arteries were 7 ± 2 and 1 ± 1 in group 1, 16 ± 4 and 3 ± 1 in group 2, and 64 ± 9 and 6 ± 2 in group 3, respectively. The significance levels were P < .005 for group 1 vs. group 2, P < .0005 for group 2 vs. group 3, and P < .00001 for group 1 vs. group 3.

Conclusion: This study demonstrates that decreased cerebrospinal fluid volume induced by choroid plexus degeneration causes cerebral thromboembolism following subarachnoid hemorrhage, which has not been previously described.

Abstract Image

查看原文本刊更多论文

脑脊液对预防脑血栓栓塞和血脑屏障破坏的意外作用:首次实验研究。

目的:探讨蛛网膜下腔出血引起的脉络膜丛损伤导致脑脊液容量减少可能导致海马动脉血栓栓塞的存在。材料与方法:选取24只家兔作为实验对象。研究组由14名受试者组成，给予0.5 mL自体血。取颞孔冠状动脉切片，同时观察脉络膜丛和海马。细胞萎缩、变暗、光晕形成和睫状体丧失被认为是变性的标准。海马体也检查了血脑屏障。比较脉络膜丛变性上皮细胞密度(n/mm3)和海马动脉血栓栓塞密度(n/cm2)。结果:组织病理学检查显示，1组脉络膜丛变性上皮细胞数为7±2个，海马动脉血栓栓塞数为1±1个，2组为16±4个，3组为64±9个，6±2个。组1 vs组2显著性水平P < 0.005，组2 vs组3显著性水平P < 0.005，组1 vs组3显著性水平P < 0.00001。结论:本研究表明，脉络膜丛变性引起的脑脊液体积减少导致蛛网膜下腔出血后的脑血栓栓塞，这在以前没有被描述过。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Eurasian Journal of Medicine Medicine-Medicine (all)

CiteScore

1.90

自引率

6.70%

发文量

审稿时长

16 weeks

期刊介绍： Eurasian Journal of Medicine (Eurasian J Med) is an international, scientific, open access periodical published by independent, unbiased, and triple-blinded peer-review principles. The journal is the official publication of Atatürk University School of Medicine and published triannually in February, June, and October. The publication language of the journal is English. The aim of the Eurasian Journal of Medicine is to publish original research papers of the highest scientific and clinical value in all medical fields. The Eurasian J Med also includes reviews, editorial short notes and letters to the editor that either as a comment related to recently published articles in our journal or as a case report. The target audience of the journal includes researchers, physicians and healthcare professionals who are interested or working in in all medical disciplines.