Association of the Interleukin-10-592C/A Polymorphism and Cervical Cancer Risk: A Meta-Analysis.

IF 1.4 4区生物学 Q4 GENETICS & HEREDITY

Genetics research Pub Date : 2022-07-12 eCollection Date: 2022-01-01 DOI:10.1155/2022/2319161

Brehima Diakite, Yaya Kassogue, Mamoudou Maiga, Guimogo Dolo, Oumar Kassogue, Jonah Musa, Imran Morhason-Bello, Ban Traore, Cheick Bougadari Traore, Bakarou Kamate, Aissata Coulibaly, Sekou Bah, Sellama Nadifi, Robert Murphy, Jane L Holl, Lifang Hou

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Abstract

A literature review showed some discrepancies regarding the association of -592C/A with the risk of cervical cancer. To allow more precise analysis of the data by increasing the number of cases studied and more acceptable generalization by considering results from different sources, the present meta-analysis was performed on available published studies that explored the relationship between SNP-592C/A of the IL-10 gene and the risk of cervical cancer. Eleven available studies, including 4187 cases and 3311 controls, were included in this study investigating the relationship between the -592C/A polymorphism of IL-10 and cervical cancer risk. Fixed-effects or random-effects models were performed with pooled odds ratios (ORs). Heterogeneity and bias tests were performed by the inconsistency test and funnel plot, respectively. The overall analysis showed an increased susceptibility to cervical cancer with the -592C/A polymorphism of the IL-10 gene for the recessive model (OR = 1.30, 95% CI = 1.14-1.49), dominant model (OR = 1.36, 95% CI = 1.09-1.70), and additive model (OR = 1.25, 95% CI = 1.09-1.44). Regarding ethnicity, a significant association of the -592C/A polymorphism of the IL-10 gene was linked to an elevated risk of cervical cancer for all genetic models (recessive, dominant, and additive) in the Asian populations and for the recessive and additive models in Caucasians with P < 0.05. The -592C/A polymorphism of the IL-10 gene may be considered a risk factor for cervical cancer.

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白细胞介素-10-592C/A 多态性与宫颈癌风险的关系：一项 Meta 分析。

文献综述显示，-592C/A 与宫颈癌风险的关系存在一些差异。为了通过增加研究病例的数量来对数据进行更精确的分析，并通过考虑不同来源的结果来进行更容易接受的归纳，本荟萃分析对已发表的探讨 IL-10 基因 SNP-592C/A 与宫颈癌风险之间关系的现有研究进行了分析。本研究共纳入了 11 项现有研究，包括 4187 例病例和 3311 例对照，这些研究均探讨了 IL-10 基因-592C/A 多态性与宫颈癌风险之间的关系。研究采用固定效应或随机效应模型，并汇总了几率比（ORs）。异质性和偏倚检验分别通过不一致性检验和漏斗图进行。总体分析结果显示，IL-10基因的-592C/A多态性在隐性模型（OR=1.30，95% CI=1.14-1.49）、显性模型（OR=1.36，95% CI=1.09-1.70）和加性模型（OR=1.25，95% CI=1.09-1.44）中均增加了宫颈癌的易感性。在种族方面，IL-10基因的-592C/A多态性与宫颈癌风险的升高有显著关联，在亚洲人群中的所有遗传模型（隐性、显性和加性）以及在白种人中的隐性和加性模型中，P<0.05。IL-10基因的-592C/A多态性可被视为宫颈癌的风险因素。

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来源期刊

Genetics research 生物-遗传学

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： Genetics Research is a key forum for original research on all aspects of human and animal genetics, reporting key findings on genomes, genes, mutations and molecular interactions, extending out to developmental, evolutionary, and population genetics as well as ethical, legal and social aspects. Our aim is to lead to a better understanding of genetic processes in health and disease. The journal focuses on the use of new technologies, such as next generation sequencing together with bioinformatics analysis, to produce increasingly detailed views of how genes function in tissues and how these genes perform, individually or collectively, in normal development and disease aetiology. The journal publishes original work, review articles, short papers, computational studies, and novel methods and techniques in research covering humans and well-established genetic organisms. Key subject areas include medical genetics, genomics, human evolutionary and population genetics, bioinformatics, genetics of complex traits, molecular and developmental genetics, Evo-Devo, quantitative and statistical genetics, behavioural genetics and environmental genetics. The breadth and quality of research make the journal an invaluable resource for medical geneticists, molecular biologists, bioinformaticians and researchers involved in genetic basis of diseases, evolutionary and developmental studies.