Role of F-18 FDG PET/CT in Predicting Response to Neoadjuvant Chemotherapy in Invasive Ductal Breast Cancer.

Tarik Sengoz, Yeliz Arman Karakaya, Aziz Gültekin, Sevda Yilmaz, Ergun Erdem, Burcu Yapar Taskoylu, Zehra Kesen, Olga Yaylali, Dogangun Yuksel
{"title":"Role of F-18 FDG PET/CT in Predicting Response to Neoadjuvant Chemotherapy in Invasive Ductal Breast Cancer.","authors":"Tarik Sengoz,&nbsp;Yeliz Arman Karakaya,&nbsp;Aziz Gültekin,&nbsp;Sevda Yilmaz,&nbsp;Ergun Erdem,&nbsp;Burcu Yapar Taskoylu,&nbsp;Zehra Kesen,&nbsp;Olga Yaylali,&nbsp;Dogangun Yuksel","doi":"10.4274/ejbh.galenos.2023.2023-1-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The role of baseline and post-treatment standardized uptake value (SUV<sub>max</sub>) values in predicting pathological response in patients with breast cancer after neoadjuvant chemotherapy (NAC).</p><p><strong>Materials and methods: </strong>Thirty patients with invasive ductal breast cancer were included in this retrospective study. F-18 fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) examinations were performed before and after NAC. Pretreatment SUV<sub>max</sub> (SUV<sub>max</sub> I), post-treatment SUV<sub>max</sub> (SUV<sub>max</sub> II) and ΔSUV<sub>max</sub> values of primary breast cancer were obtained. Breast tumor pathology preparations were examined for the evaluation of tumor response according to the Miller and Payne classification. Patients were grouped as responding to treatment (pCR) and unresponsive to treatment (nonpCR). In all analyses, p<0.05 was considered statistically significant.</p><p><strong>Results: </strong>The mean age of the 30 patients included in the study was 51.2±11.98 years. In the study-defined grouping, 13 patients (43.3%) were nonresponders and 17 patients (56.7%) were responders. ΔSUV<sub>max</sub> was significantly greater in the responders group compared to the nonresponders group, while SUV<sub>max</sub> II was lower (<i>p</i> = 0.001 and <i>p</i> = 0.004, respectively). There was no significant difference between the responders and nonresponders in terms of age, tumor diameter, and SUV<sub>max</sub> I values. Multivariate logistic regression analysis showed ΔSUV<sub>max</sub> to be the only independent predictive factor for pCR.</p><p><strong>Conclusion: </strong>F-18 FDG PET/CT was an effective method in evaluating the treatment response after NAC in breast cancer, and ΔSUV<sub>max</sub> and post-treatment SUV<sub>max</sub> can be used to predict the response of the primary tumor to treatment.</p>","PeriodicalId":11885,"journal":{"name":"European journal of breast health","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071889/pdf/ejbh-19-159.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European journal of breast health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4274/ejbh.galenos.2023.2023-1-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

Abstract

Objective: The role of baseline and post-treatment standardized uptake value (SUVmax) values in predicting pathological response in patients with breast cancer after neoadjuvant chemotherapy (NAC).

Materials and methods: Thirty patients with invasive ductal breast cancer were included in this retrospective study. F-18 fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) examinations were performed before and after NAC. Pretreatment SUVmax (SUVmax I), post-treatment SUVmax (SUVmax II) and ΔSUVmax values of primary breast cancer were obtained. Breast tumor pathology preparations were examined for the evaluation of tumor response according to the Miller and Payne classification. Patients were grouped as responding to treatment (pCR) and unresponsive to treatment (nonpCR). In all analyses, p<0.05 was considered statistically significant.

Results: The mean age of the 30 patients included in the study was 51.2±11.98 years. In the study-defined grouping, 13 patients (43.3%) were nonresponders and 17 patients (56.7%) were responders. ΔSUVmax was significantly greater in the responders group compared to the nonresponders group, while SUVmax II was lower (p = 0.001 and p = 0.004, respectively). There was no significant difference between the responders and nonresponders in terms of age, tumor diameter, and SUVmax I values. Multivariate logistic regression analysis showed ΔSUVmax to be the only independent predictive factor for pCR.

Conclusion: F-18 FDG PET/CT was an effective method in evaluating the treatment response after NAC in breast cancer, and ΔSUVmax and post-treatment SUVmax can be used to predict the response of the primary tumor to treatment.

F-18 FDG PET/CT在预测浸润性导管性乳腺癌新辅助化疗反应中的作用
目的:基线和治疗后标准化摄取值(SUVmax)值在预测乳腺癌患者新辅助化疗(NAC)后病理反应中的作用。材料与方法:对30例浸润性导管性乳腺癌患者进行回顾性研究。NAC前后分别进行F-18氟脱氧葡萄糖(FDG)正电子发射断层扫描/计算机断层扫描(PET/CT)检查。获得原发性乳腺癌治疗前SUVmax (SUVmax I)、治疗后SUVmax (SUVmax II)及ΔSUVmax值。根据Miller和Payne分类检查乳腺肿瘤病理准备以评估肿瘤反应。将患者分为对治疗有反应(pCR)和对治疗无反应(nonpCR)。结果:纳入研究的30例患者的平均年龄为51.2±11.98岁。在研究定义的分组中,13例(43.3%)患者无反应,17例(56.7%)患者有反应。反应组ΔSUVmax显著高于无反应组,而SUVmax II较低(分别为p = 0.001和p = 0.004)。应答者和无应答者在年龄、肿瘤直径和SUVmax I值方面无显著差异。多因素logistic回归分析显示ΔSUVmax是pCR的唯一独立预测因子。结论:F-18 FDG PET/CT是评价乳腺癌NAC后治疗反应的有效方法,ΔSUVmax和治疗后SUVmax可用于预测原发肿瘤对治疗的反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信