{"title":"L-Tartaric Acid Inhibits Diminazene-induced Vasorelaxation in Isolated Rat Aorta.","authors":"Ayoub Amssayef, Ismail Bouadid, Mohamed Eddouks","doi":"10.2174/1871525721666230406075646","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims: </strong>The study investigated the effect of L-tartaric acid on diminazene-indiuced vasorelaxation.</p><p><strong>Background: </strong>Diminazene is known to induce vasorelaxation through the stimulation of angiotensin- converting enzyme (ACE-2).</p><p><strong>Objective: </strong>This work was designed to study the effect of L-tartaric acid on diminazene-induced vasorelaxation using an <i>ex vivo</i> approach.</p><p><strong>Materials and methods: </strong>In the current investigation, the inhibitory effect of L-tartaric acid on diminazene-induced relaxation.</p><p><strong>Results: </strong>The results confirmed that L-tartaric acid was able to inhibit in a dose-dependent manner diminazene-induced vasorelaxation.</p><p><strong>Conclusion: </strong>This investigation provides important experimental evidence of the efficacy of Ltartaric acid in inhibiting diminazene-induced vasorelaxation.</p>","PeriodicalId":9535,"journal":{"name":"Cardiovascular and Hematological Agents in Medicinal Chemistry","volume":" ","pages":"83-89"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cardiovascular and Hematological Agents in Medicinal Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1871525721666230406075646","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Aims: The study investigated the effect of L-tartaric acid on diminazene-indiuced vasorelaxation.
Background: Diminazene is known to induce vasorelaxation through the stimulation of angiotensin- converting enzyme (ACE-2).
Objective: This work was designed to study the effect of L-tartaric acid on diminazene-induced vasorelaxation using an ex vivo approach.
Materials and methods: In the current investigation, the inhibitory effect of L-tartaric acid on diminazene-induced relaxation.
Results: The results confirmed that L-tartaric acid was able to inhibit in a dose-dependent manner diminazene-induced vasorelaxation.
Conclusion: This investigation provides important experimental evidence of the efficacy of Ltartaric acid in inhibiting diminazene-induced vasorelaxation.
期刊介绍：
Cardiovascular & Hematological Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new Cardiovascular & Hematological Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Cardiovascular & Hematological medicinal chemistry. Cardiovascular & Hematological Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cardiovascular & hematological drug discovery.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
