CRAB score for prediction of colectomy within 2 years following admission for acute severe ulcerative colitis.

IF 1.9 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Saudi Journal of Gastroenterology Pub Date : 2023-09-01 DOI:10.4103/sjg.sjg_521_22

Krishnadas Devadas, Suprabhat Giri, Jijo Varghese, Antony George

{"title":"CRAB score for prediction of colectomy within 2 years following admission for acute severe ulcerative colitis.","authors":"Krishnadas Devadas, Suprabhat Giri, Jijo Varghese, Antony George","doi":"10.4103/sjg.sjg_521_22","DOIUrl":null,"url":null,"abstract":"Background: The Oxford and Swedish indexes were developed to predict in-hospital colectomy in acute severe ulcerative colitis (ASUC), but not long-term prediction, and all these indexes were based on Western data. Our study aimed to analyze the predictors of colectomy within 3 years of ASUC in an Indian cohort and derive a simple predictive score.Methods: A prospective observational study was conducted in a tertiary health care center in South India over a period of 5 years. All patients admitted with ASUC were followed up for a period of 24 months after the index admission, to look for progression to colectomy.Results: A total of 81 (47 male) patients were included in the derivation cohort. Fifteen (18.5%) patients required colectomy during a follow-up period of 24 months. On regression analysis, C-reactive protein (CRP) and serum albumin were independent predictors of 24-month colectomy. The CRAB (CRP + AlBumin) score was obtained by multiplying coefficient of beta to albumin and CRP (CRAB score = CRP x 0.2 - Albumin x 0.26). The CRAB score demonstrated an AUROC of 0.923 and a score of >0.4 with a sensitivity of 82% and specificity of 92% for the prediction of 2-year colectomy following ASUC. The score was validated in a validation cohort of 31 patients, and at >0.4, the score had a sensitivity of 83% and a specificity of 96% in predicting colectomy.Conclusion: CRAB score is a simple prognostic score that can predict 2-year colectomy in ASUC patients with high sensitivity and specificity.","PeriodicalId":48881,"journal":{"name":"Saudi Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10644996/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Saudi Journal of Gastroenterology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/sjg.sjg_521_22","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The Oxford and Swedish indexes were developed to predict in-hospital colectomy in acute severe ulcerative colitis (ASUC), but not long-term prediction, and all these indexes were based on Western data. Our study aimed to analyze the predictors of colectomy within 3 years of ASUC in an Indian cohort and derive a simple predictive score.

Methods: A prospective observational study was conducted in a tertiary health care center in South India over a period of 5 years. All patients admitted with ASUC were followed up for a period of 24 months after the index admission, to look for progression to colectomy.

Results: A total of 81 (47 male) patients were included in the derivation cohort. Fifteen (18.5%) patients required colectomy during a follow-up period of 24 months. On regression analysis, C-reactive protein (CRP) and serum albumin were independent predictors of 24-month colectomy. The CRAB (CRP + AlBumin) score was obtained by multiplying coefficient of beta to albumin and CRP (CRAB score = CRP x 0.2 - Albumin x 0.26). The CRAB score demonstrated an AUROC of 0.923 and a score of >0.4 with a sensitivity of 82% and specificity of 92% for the prediction of 2-year colectomy following ASUC. The score was validated in a validation cohort of 31 patients, and at >0.4, the score had a sensitivity of 83% and a specificity of 96% in predicting colectomy.

Conclusion: CRAB score is a simple prognostic score that can predict 2-year colectomy in ASUC patients with high sensitivity and specificity.

查看原文本刊更多论文

CRAB评分预测急性严重溃疡性结肠炎入院后2年内结肠切除术。

背景：牛津和瑞典的指数是为了预测急性严重溃疡性结肠炎（ASUC）的住院结肠切除术，而不是长期预测，所有这些指数都是基于西方数据。我们的研究旨在分析印度队列中ASUC 3年内结肠切除术的预测因素，并得出一个简单的预测分数。方法：在南印度的一家三级医疗保健中心进行为期5年的前瞻性观察性研究。所有入住ASUC的患者在指数入院后随访24个月，以寻找结肠切除术的进展。结果：共有81名（47名男性）患者被纳入衍生队列。在24个月的随访期内，15名（18.5%）患者需要结肠切除术。回归分析显示，C反应蛋白（CRP）和血清白蛋白是24个月结肠切除术的独立预测因素。CRAB（CRP+AlBumin）评分是通过将β与白蛋白和CRP的系数相乘获得的（CRAB评分=CRP x 0.2-白蛋白x 0.26）。CRAB评分显示AUROC为0.923，评分>0.4，预测ASUC后2年结肠切除术的敏感性为82%，特异性为92%。该评分在一个由31名患者组成的验证队列中进行了验证，在>0.4时，该评分在预测结肠切除术方面的敏感性为83%，特异性为96%。结论：CRAB评分是一种简单的预后评分，可预测ASUC患者2年结肠切除术，具有较高的敏感性和特异性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Saudi Journal of Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.40

自引率

3.70%

发文量

审稿时长

28 weeks

期刊介绍： The Saudi Journal of Gastroenterology (SJG) is an open access peer-reviewed publication. Authors are invited to submit articles in the field of gastroenterology, hepatology and nutrition, with a wide spectrum of coverage including basic science, epidemiology, diagnostics, therapeutics, public health, and standards of health care in relation to the concerned specialty. Review articles are usually by invitation. However review articles of current interest and a high standard of scientific value could also be considered for publication.