Pure Tubular Breast Carcinoma: Clinicopathological Characteristics and Clinical Outcomes.

Selman Emiroglu, Asmaa Mahmoud Abuaisha, Mustafa Tukenmez, Neslihan Cabioglu, Aysel Bayram, Vahit Ozmen, Mahmut Muslumanoglu
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Abstract

Objective: Tubular breast carcinoma (TBC) is a rare subtype of breast carcinoma (BC) with a good prognosis. In this study, we aimed to assess the clinicopathological characteristics of pure TBC (PTBC), analyze factors that may influence long-term prognosis, examine the frequency of axillary lymph node metastasis (ALNM), and discuss the need for axillary surgery in PTBC.

Materials and methods: Fifty-four Patients diagnosed with PTBC between January 2003 and December 2020 at Istanbul Faculty of Medicine were included. Clinicopathological, surgical, treatment, and overall survival (OS) data were analyzed.

Results: A total of 54 patients with a mean age of 52.2 years were assessed. The mean size of the tumor was 10.6 mm. Four (7.4%) patients had not undergone axillary surgery, while thirty-eight (70.4%) had undergone sentinel lymph node biopsy and twelve (22.2%) had undergone axillary lymph node dissection (ALND). Significantly, four (33.3%) of those who had undergone ALND had tumor grade 2 (p = 0.020) and eight of them (66.7%) had ALNM. Fifty percent (50%) of patients who were treated with chemotherapy had grade 2 and multifocal tumors and ALNM. Moreover, the frequency of ALNM was higher in patients with tumor diameters greater than 10 mm. Median follow-up time was 80 months (12-220). None of the patients had locoregional recurrence, but one patient had systemic metastasis. Furthermore, five-year OS was 97.9%, while ten-year OS was 93.6%.

Conclusion: PTBC is associated with favorable prognosis, good clinical outcomes and high survival rate, with rare recurrences and metastases.

纯管状乳腺癌:临床病理特征和临床结果。
目的:管状乳腺癌(TBC)是一种少见的乳腺癌亚型,预后良好。在本研究中,我们旨在评估纯TBC (PTBC)的临床病理特征,分析可能影响长期预后的因素,检查腋窝淋巴结转移(ALNM)的频率,并讨论PTBC是否需要腋窝手术。材料和方法:纳入2003年1月至2020年12月在伊斯坦布尔医学院诊断为PTBC的54例患者。分析临床病理、手术、治疗和总生存期(OS)数据。结果:共纳入54例患者,平均年龄52.2岁。肿瘤平均大小10.6 mm。4例(7.4%)未行腋窝手术,38例(70.4%)行前哨淋巴结活检,12例(22.2%)行腋窝淋巴结清扫(ALND)。值得注意的是,4例(33.3%)行ALND的患者为2级肿瘤(p = 0.020), 8例(66.7%)为ALNM。50%接受化疗的患者为2级、多灶性肿瘤和ALNM。此外,在肿瘤直径大于10 mm的患者中,ALNM的发生率更高。中位随访时间为80个月(12-220)。所有患者均无局部复发,但有1例发生全身转移。5年OS为97.9%,10年OS为93.6%。结论:PTBC预后良好,临床疗效好,生存率高,复发转移少。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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