A genome-wide association study identified new variants associated with mathematical abilities in Chinese children

IF 2.4 4区 心理学 Q2 BEHAVIORAL SCIENCES
Liming Zhang, Zhengjun Wang, Zijian Zhu, Qing Yang, Chen Cheng, Shunan Zhao, Chunyu Liu, Jingjing Zhao
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引用次数: 2

Abstract

Mathematical ability is moderately heritable, and it is a complex trait which can be evaluated in several different categories. A few genetic studies have been published on general mathematical ability. However, no genetic study focused on specific mathematical ability categories. In this study, we separately performed genome-wide association studies on 11 mathematical ability categories in 1146 students from Chinese elementary schools. We identified seven genome-wide significant single nucleotide polymorphisms (SNPs) with strong linkage disequilibrium among each other (all r2 > 0.8) associated with mathematical reasoning ability (top SNP: rs34034296, p = 2.01 × 10−8, nearest gene: CUB and Sushi multiple domains 3, CSMD3). We replicated one SNP (rs133885) from 585 SNPs previously reported to be associated with general mathematical ability associated with division ability in our data (p = 1.053 × 10−5). In the gene- and gene-set enrichment analysis by MAGMA, we found three significant enrichments of associations with three mathematical ability categories for three genes (LINGO2, OAS1 and HECTD1). We also observed four significant enrichments of associations with four mathematical ability categories for three gene sets. Our results suggest new candidate genetic loci for the genetics of mathematical ability.

Abstract Image

一项全基因组关联研究发现了与中国儿童数学能力相关的新变异
数学能力是中等遗传的,它是一个复杂的性状,可以用几个不同的类别来评估。一些关于一般数学能力的基因研究已经发表。然而,没有遗传学研究关注具体的数学能力类别。在本研究中,我们分别对1146名中国小学生的11个数学能力类别进行了全基因组关联研究。我们发现了7个与数学推理能力相关的全基因组显著单核苷酸多态性(SNP),它们之间存在强烈的连锁不平衡(r2 > 0.8)(最高SNP: rs34034296, p = 2.01 × 10−8,最近基因:CUB和Sushi多域3,CSMD3)。我们从先前报道的585个SNP中复制了一个SNP (rs133885),这些SNP与我们的数据中与分裂能力相关的一般数学能力相关(p = 1.053 × 10−5)。在MAGMA的基因和基因集富集分析中,我们发现三个基因(LINGO2、OAS1和hector 1)与三个数学能力类别的关联有三个显著的富集。我们还观察到三个基因集与四个数学能力类别的关联有四个显著的富集。我们的研究结果为数学能力的遗传提供了新的候选遗传位点。
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来源期刊
Genes Brain and Behavior
Genes Brain and Behavior 医学-行为科学
CiteScore
6.80
自引率
4.00%
发文量
62
审稿时长
4-8 weeks
期刊介绍: Genes, Brain and Behavior was launched in 2002 with the aim of publishing top quality research in behavioral and neural genetics in their broadest sense. The emphasis is on the analysis of the behavioral and neural phenotypes under consideration, the unifying theme being the genetic approach as a tool to increase our understanding of these phenotypes. Genes Brain and Behavior is pleased to offer the following features: 8 issues per year online submissions with first editorial decisions within 3-4 weeks and fast publication at Wiley-Blackwells High visibility through its coverage by PubMed/Medline, Current Contents and other major abstracting and indexing services Inclusion in the Wiley-Blackwell consortial license, extending readership to thousands of international libraries and institutions A large and varied editorial board comprising of international specialists.
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