Prognostic Factors Influencing Progression-Free Survival in HER2-Positive Metastatic Breast Cancer Patients Who Were Treated With A Combination of Lapatinib and Capecitabine.

İzzet Doğan, Nail Paksoy, Naziye Ak, Sezai Vatansever, Pınar Saip, Adnan Aydıner
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Abstract

Objective: The aim was to assess the prognostic variables in human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer patients receiving lapatinib plus capecitabine.

Materials and methods: Retrospective data on HER2-positive metastatic breast cancer patients who received lapatinib and capecitabine were analyzed. Survival outcome was obtained with Cox regression analysis and the Kaplan-Meier method.

Results: The study included 102 patients. Forty-four (43.1%) patients had de novo metastatic disease. The most frequent metastatic sites were, in order, bone (61.8%), brain (57.8%), liver (35.3%), and lung (34.3%). All of the patients had previously received chemotherapy based on trastuzumab. With combined lapatinib and capecitabine, complete response was observed in 7.8%, partial response in 30.4%, and stable disease in 24.5%. Progression-free survival was 8 (95% confidence interval, 5.1-10.8) months. In multivariable analysis, endocrine therapy (p = 0.02), de novo metastatic disease (p = 0.02), and age (p = 0.02) were prognostic factors for progression-free survival. However, the number of chemotherapy cycles with trastuzumab, palliative radiotherapy, history of breast surgery, and the number of metastatic sites were not significant in this respect.

Conclusion: These results have demonstrated the effectiveness of lapatinib plus capecitabine in metastatic HER2-positive breast cancer patients. Furthermore, unfavorable prognostic factors for progression-free survival were shown to be hormone-negative tumor, de novo metastatic disease, and young age.

影响拉帕替尼和卡培他滨联合治疗her2阳性转移性乳腺癌患者无进展生存期的预后因素
目的:评估人表皮生长因子受体2 (HER2)阳性转移性乳腺癌患者接受拉帕替尼加卡培他滨治疗后的预后变量。材料和方法:回顾性分析her2阳性转移性乳腺癌患者接受拉帕替尼和卡培他滨治疗的资料。生存结局采用Cox回归分析和Kaplan-Meier法。结果:纳入102例患者。44例(43.1%)患者有新发转移性疾病。最常见的转移部位依次为骨(61.8%)、脑(57.8%)、肝(35.3%)和肺(34.3%)。所有患者之前都接受过基于曲妥珠单抗的化疗。联合使用拉帕替尼和卡培他滨,完全缓解率为7.8%,部分缓解率为30.4%,病情稳定率为24.5%。无进展生存期为8个月(95%可信区间,5.1-10.8)。在多变量分析中,内分泌治疗(p = 0.02)、新发转移性疾病(p = 0.02)和年龄(p = 0.02)是无进展生存期的预后因素。然而,曲妥珠单抗化疗周期、姑息性放疗、乳房手术史和转移部位数量在这方面没有显著性差异。结论:这些结果证明了拉帕替尼联合卡培他滨治疗转移性her2阳性乳腺癌患者的有效性。此外,无进展生存期的不利预后因素显示为激素阴性肿瘤、新发转移性疾病和年轻。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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