Increasing resolution in stress neurobiology: from single cells to complex group behaviors.

IF 2.6 4区 心理学 Q2 BEHAVIORAL SCIENCES
Lucas Miranda, Joeri Bordes, Serena Gasperoni, Juan Pablo Lopez
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引用次数: 2

Abstract

Stress can have severe psychological and physiological consequences. Thus, inappropriate regulation of the stress response is linked to the etiology of mood and anxiety disorders. The generation and implementation of preclinical animal models represent valuable tools to explore and characterize the mechanisms underlying the pathophysiology of stress-related psychiatric disorders and the development of novel pharmacological strategies. In this commentary, we discuss the strengths and limitations of state-of-the-art molecular and computational advances employed in stress neurobiology research, with a focus on the ever-increasing spatiotemporal resolution in cell biology and behavioral science. Finally, we share our perspective on future directions in the fields of preclinical and human stress research.

增加压力神经生物学的分辨率:从单细胞到复杂的群体行为。
压力会产生严重的心理和生理后果。因此,对应激反应的不适当调节与情绪和焦虑障碍的病因有关。临床前动物模型的建立和实施为探索和表征应激相关精神疾病的病理生理机制以及开发新的药理策略提供了有价值的工具。在这篇评论中,我们讨论了压力神经生物学研究中使用的最先进的分子和计算技术的优势和局限性,重点是细胞生物学和行为科学中不断增加的时空分辨率。最后,我们对临床前和人类应激研究的未来方向进行了展望。
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来源期刊
CiteScore
5.60
自引率
0.00%
发文量
25
审稿时长
6-12 weeks
期刊介绍: The journal Stress aims to provide scientists involved in stress research with the possibility of reading a more integrated view of the field. Peer reviewed papers, invited reviews and short communications will deal with interdisciplinary aspects of stress in terms of: the mechanisms of stressful stimulation, including within and between individuals; the physiological and behavioural responses to stress, and their regulation, in both the short and long term; adaptive mechanisms, coping strategies and the pathological consequences of stress. Stress will publish the latest developments in physiology, neurobiology, molecular biology, genetics research, immunology, and behavioural studies as they impact on the understanding of stress and its adverse consequences and their amelioration. Specific approaches may include transgenic/knockout animals, developmental/programming studies, electrophysiology, histochemistry, neurochemistry, neuropharmacology, neuroanatomy, neuroimaging, endocrinology, autonomic physiology, immunology, chronic pain, ethological and other behavioural studies and clinical measures.
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