Highly Miniaturized, Low-Power CMOS ASIC Chip for Long-Term Continuous Glucose Monitoring.

IF 4.1 Q2 ENDOCRINOLOGY & METABOLISM
Raja Hari Gudlavalleti, Xiangyi Xi, Allen Legassey, Pik-Yiu Chan, Jin Li, Diane Burgess, Charles Giardina, Fotios Papadimitrakopoulos, Faquir Jain
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引用次数: 0

Abstract

Background: The objective of this work is to develop a highly miniaturized, low-power, biosensing platform for continuous glucose monitoring (CGM). This platform is based on an application-specific integrated circuit (ASIC) chip that interfaces with an amperometric glucose-sensing element. To reduce both size and power requirements, this custom ASIC chip was implemented using 65-nm complementary metal oxide semiconductor (CMOS) technology node. Interfacing this chip to a frequency-counting microprocessor with storage capabilities, a miniaturized transcutaneous CGM system can be constructed for small laboratory animals, with long battery life.

Method: A 0.45 mm × 1.12 mm custom ASIC chip was first designed and implemented using the Taiwan Semiconductor Manufacturing Company (TSMC) 65-nm CMOS technology node. This ASIC chip was then interfaced with a multi-layer amperometric glucose-sensing element and a frequency-counting microprocessor with storage capabilities. Variation in glucose levels generates a linear increase in frequency response of this ASIC chip. In vivo experiments were conducted in healthy Sprague Dawley rats.

Results: This highly miniaturized, 65-nm custom ASIC chip has an overall power consumption of circa 36 µW. In vitro testing shows that this ASIC chip produces a linear (R2 = 99.5) frequency response to varying glucose levels (from 2 to 25 mM), with a sensitivity of 1278 Hz/mM. In vivo testing in unrestrained healthy rats demonstrated long-term CGM (six days/per charge) with rapid glucose response to glycemic variations induced by isoflurane anesthesia and tail vein injection.

Conclusions: The miniature footprint of the biosensor platform, together with its low-power consumption, renders this CMOS ASIC chip a versatile platform for a variety of highly miniaturized devices, intended to improve the quality of life of patients with type 1 and type 2 diabetes.

用于长期连续葡萄糖监测的高度微型化、低功耗 CMOS ASIC 芯片。
背景:这项工作的目的是开发一种高度微型化、低功耗、用于连续葡萄糖监测(CGM)的生物传感平台。该平台基于一个与安培葡萄糖传感元件连接的专用集成电路(ASIC)芯片。为了减小尺寸和降低功耗要求,该定制 ASIC 芯片采用 65 纳米互补金属氧化物半导体 (CMOS) 技术节点实现。将该芯片与具有存储功能的计频微处理器连接,就可以为小型实验动物构建一个微型经皮血糖监测系统,而且电池寿命长:方法:首先使用台湾半导体制造公司(TSMC)65 纳米 CMOS 技术节点设计并实现了一个 0.45 毫米 × 1.12 毫米的定制 ASIC 芯片。然后,将该 ASIC 芯片与多层安培葡萄糖传感元件和具有存储功能的频率计数微处理器连接起来。葡萄糖水平的变化会使该 ASIC 芯片的频率响应线性增加。在健康的 Sprague Dawley 大鼠身上进行了体内实验:这款高度微型化的 65 纳米定制 ASIC 芯片的总功耗约为 36 µW。体外测试表明,该 ASIC 芯片对不同葡萄糖水平(从 2 毫摩尔到 25 毫摩尔)的频率响应呈线性(R2 = 99.5),灵敏度为 1278 赫兹/毫摩尔。在不受约束的健康大鼠体内进行的测试表明,长期 CGM(六天/每次充电)对异氟烷麻醉和尾静脉注射引起的血糖变化具有快速的葡萄糖响应:该生物传感器平台体积小、功耗低,使这种 CMOS ASIC 芯片成为各种高度微型化设备的多功能平台,旨在改善 1 型和 2 型糖尿病患者的生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Diabetes Science and Technology
Journal of Diabetes Science and Technology Medicine-Internal Medicine
CiteScore
7.50
自引率
12.00%
发文量
148
期刊介绍: The Journal of Diabetes Science and Technology (JDST) is a bi-monthly, peer-reviewed scientific journal published by the Diabetes Technology Society. JDST covers scientific and clinical aspects of diabetes technology including glucose monitoring, insulin and metabolic peptide delivery, the artificial pancreas, digital health, precision medicine, social media, cybersecurity, software for modeling, physiologic monitoring, technology for managing obesity, and diagnostic tests of glycation. The journal also covers the development and use of mobile applications and wireless communication, as well as bioengineered tools such as MEMS, new biomaterials, and nanotechnology to develop new sensors. Articles in JDST cover both basic research and clinical applications of technologies being developed to help people with diabetes.
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