Adipose Tissue Remodeling in Pathophysiology.

IF 28.4 1区 医学 Q1 PATHOLOGY
Christopher Auger, Shingo Kajimura
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引用次数: 16

Abstract

Rather than serving as a mere onlooker, adipose tissue is a complex endocrine organ and active participant in disease initiation and progression. Disruptions of biological processes operating within adipose can disturb healthy systemic physiology, the sequelae of which include metabolic disorders such as obesity and type 2 diabetes. A burgeoning interest in the field of adipose research has allowed for the elucidation of regulatory networks underlying both adipose tissue function and dysfunction. Despite this progress, few diseases are treated by targeting maladaptation in the adipose, an oft-overlooked organ. In this review, we elaborate on the distinct subtypes of adipocytes, their developmental origins and secretory roles, and the dynamic interplay at work within the tissue itself. Central to this discussion is the relationship between adipose and disease states, including obesity, cachexia, and infectious diseases, as we aim to leverage our wealth of knowledge for the development of novel and targeted therapeutics.

病理生理学中的脂肪组织重塑。
脂肪组织不仅仅是一个旁观者,而是一个复杂的内分泌器官,是疾病发生和发展的积极参与者。在脂肪中运作的生物过程的中断会扰乱健康的全身生理,其后遗症包括代谢紊乱,如肥胖和2型糖尿病。在脂肪研究领域蓬勃发展的兴趣已经允许阐明脂肪组织功能和功能障碍背后的调节网络。尽管取得了这些进展,但很少有疾病是通过针对脂肪的不适应来治疗的,脂肪是一个经常被忽视的器官。在这篇综述中,我们详细介绍了脂肪细胞的不同亚型,它们的发育起源和分泌作用,以及在组织内部工作的动态相互作用。讨论的核心是脂肪和疾病状态之间的关系,包括肥胖、恶病质和传染病,因为我们的目标是利用我们丰富的知识来开发新的靶向治疗方法。
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来源期刊
CiteScore
62.60
自引率
0.00%
发文量
40
期刊介绍: The Annual Review of Pathology: Mechanisms of Disease is a scholarly journal that has been published since 2006. Its primary focus is to provide a comprehensive overview of recent advancements in our knowledge of the causes and development of significant human diseases. The journal places particular emphasis on exploring the current and evolving concepts of disease pathogenesis, as well as the molecular genetic and morphological changes associated with various diseases. Additionally, the journal addresses the clinical significance of these findings. In order to increase accessibility and promote the broad dissemination of research, the current volume of the journal has transitioned from a gated subscription model to an open access format. This change has been made possible through the Annual Reviews' Subscribe to Open program, which allows all articles published in this volume to be freely accessible to readers. As part of this transition, all articles in the journal are published under a Creative Commons Attribution (CC BY) license, which encourages open sharing and use of the research.
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