A large-scale study on the seroprevalence of Toxoplasma gondii infection in humans in Iran.

IF 1.5 4区医学 Q3 PARASITOLOGY

Folia Parasitologica Pub Date : 2023-02-01 DOI:10.14411/fp.2023.004

Reza Kalantari, Mahsa Esmaeilifallah, Rasool Jafari, Hossein Mirhendi Esfahani, Hossein Yousofi Darani

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引用次数: 1

Abstract

It is estimated that nearly one-third of the world's human population is infected with Toxoplasma gondii (Nicolle et Manceaux, 1908). Human infection is commonly asymptomatic, multifaceted, and can manifest in severe pathological forms in congenital toxoplasmosis and immunocompromised individuals. This study attempted to recognise the seroprevalence of T. gondii infection in Iranian residents referred to medical laboratories for toxoplasmosis tests throughout the country. This retrospective cross-sectional study was conducted from 2015 to 2019 on individuals referred to diagnostic laboratories in 26 provinces, and these laboratories sent their samples to the referral centres. Accordingly, data associated with serodiagnosis of toxoplasmosis, age, sex, anti-T. gondii IgG, and IgM status in Iranian residents were collected from two referral diagnostic laboratories. All individuals were evaluated using the antibody immunocapture-chemiluminescence assay (CLIA) method with the Immulite^®2000s XPi system. In this study, the first large-scale assay of T. gondii infection in Iran, an overall seroprevalence of 30.4% was among 35,047 patients examined. The highest IgM seropositivity rate was in the 10-20 years old patients. In addition, this study showed a very different prevalence of T. gondii across the country, highest in the humid areas, such as the Caspian Sea basin in the North, and the North West with seroprevalence of 48.6%.

查看原文本刊更多论文

伊朗人刚地弓形虫感染血清流行率的大规模研究。

据估计，全世界近三分之一的人口感染了刚地弓形虫(Nicolle et Manceaux, 1908)。人类感染通常是无症状的，多方面的，在先天性弓形虫病和免疫功能低下的个体中可以表现为严重的病理形式。这项研究试图确认伊朗全国各地转诊到医学实验室进行弓形虫病检测的伊朗居民中弓形虫感染的血清流行率。这项回顾性横断面研究于2015年至2019年对26个省的诊断实验室转诊的个体进行了研究，这些实验室将其样本送到转诊中心。因此，与弓形虫病的血清诊断、年龄、性别、抗t抗体相关的数据。从两个转诊诊断实验室收集伊朗居民的弓形虫IgG和IgM状况。所有个体使用抗体免疫捕获-化学发光试验(CLIA)方法与Immulite®2000 XPi系统进行评估。在这项研究中，伊朗首次进行了弓形虫感染的大规模检测，在35047名接受检测的患者中，总血清阳性率为30.4%。IgM血清阳性率以10 ~ 20岁患者最高。此外，本研究显示弓形虫在全国的流行率差异很大，在潮湿地区，如北部的里海盆地和西北部，血清阳性率最高，为48.6%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Folia Parasitologica 医学-寄生虫学

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： FOLIA PARASITOLOGICA, issued in online versions, is an international journal that covers the whole field of general, systematic, ecological and experimental parasitology. It publishes original research papers, research notes and review articles. Contributions from all branches of animal parasitology, such as morphology, taxonomy, biology, biochemistry, physiology, immunology, molecular biology and evolution of parasites, and host-parasite relationships, are eligible. Novelty and importance in the international (not local or regional) context are required. New geographical records of parasites, records of new hosts, regional parasite and/or host surveys (if they constitute the principal substance of manuscript), local/regional prevalence surveys of diseases, local/regional studies on epidemiology of well known diseases and of parasite impact on human/animal health, case reports, routine clinical studies and testing of established diagnostic or treatment procedures, will not be considered. One species description will also not be considered unless they include more general information, such as new diagnostic characters, host-parasite associations, phylogenetic implications, etc. Manuscripts found suitable on submission will be reviewed by at least two reviewers.