Telomere length and telomerase activity of leukocytes as biomarkers of selective serotonin reuptake inhibitor responses in patients with major depressive disorder.

IF 1.5 4区医学 Q4 GENETICS & HEREDITY

Psychiatric Genetics Pub Date : 2022-02-01 DOI:10.1097/YPG.0000000000000305

Raiany S da Silva, Leopoldo S de Moraes, Carlos A M da Rocha, Hygor Ferreira-Fernandes, France K N Yoshioka, Juan A Rey, Giovanny R Pinto, Rommel R Burbano

引用次数: 3

Abstract

We analyze the leukocyte telomere length (LTL) and telomerase activity in patients with major depressive disorder (MDD) before and after treatment with selective serotonin reuptake inhibitors (SSRIs). Before treatment, there was a reduction in the LTLs and expression levels of the human telomerase reverse transcriptase (hTERT) in the patients with MDD compared with controls. However, after 24 weeks of treatment with SSRIs, there was a significant increase in the LTLs and the expression levels of hTERT, with values approaching those observed in the controls. We conclude that SSRI antidepressant therapy can directly influence the increased expression levels of hTERT in patients.

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白细胞端粒长度和端粒酶活性作为重性抑郁症患者选择性血清素再摄取抑制剂反应的生物标志物。

我们分析了选择性血清素再摄取抑制剂(SSRIs)治疗前后重度抑郁症(MDD)患者白细胞端粒长度(LTL)和端粒酶活性的变化。治疗前，与对照组相比，MDD患者的LTLs和人类端粒酶逆转录酶(hTERT)表达水平降低。然而，在使用SSRIs治疗24周后，ltl和hTERT的表达水平显著增加，接近对照组的值。我们得出结论，SSRI抗抑郁治疗可以直接影响患者hTERT表达水平的升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatric Genetics 医学-神经科学

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： The journal aims to publish papers which bring together clinical observations, psychological and behavioural abnormalities and genetic data. All papers are fully refereed. Psychiatric Genetics is also a forum for reporting new approaches to genetic research in psychiatry and neurology utilizing novel techniques or methodologies. Psychiatric Genetics publishes original Research Reports dealing with inherited factors involved in psychiatric and neurological disorders. This encompasses gene localization and chromosome markers, changes in neuronal gene expression related to psychiatric disease, linkage genetics analyses, family, twin and adoption studies, and genetically based animal models of neuropsychiatric disease. The journal covers areas such as molecular neurobiology and molecular genetics relevant to mental illness. Reviews of the literature and Commentaries in areas of current interest will be considered for publication. Reviews and Commentaries in areas outside psychiatric genetics, but of interest and importance to Psychiatric Genetics, will also be considered. Psychiatric Genetics also publishes Book Reviews, Brief Reports and Conference Reports.