Study of the Antihypertensive Effect of Laurus nobilis in Rats.

Q2 Medicine

Cardiovascular and Hematological Agents in Medicinal Chemistry Pub Date : 2023-01-01 DOI:10.2174/1871525720666220512154041

Ismail Bouadid, Ayoub Amssayef, Mohamed Eddouks

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引用次数: 1

Abstract

Aims: The study aimed to study the antihypertensive activity of Laurus nobilis.

Background: Laurus nobilis L. is used to treat hypertension in Morocco.

Objective: The study was designed to investigate the effect of the aqueous extract leaves of Laurus nobilis (AELN) on blood pressure.

Materials and methods: The antihypertensive and vasorelaxant activities of AELN were pharmacologically investigated in normotensive and L-NAME-induced hypertensive rats. Thereafter, blood pressure was evaluated, and the ex-vivo vasorelaxant activity of this extract was performed.

Results: A considerable decrease in blood pressure parameters were observed in L-NAMEinduced hypertensive rats treated with AELN. The extract induced a vasorelaxant effect on the aorta precontracted with epinephrine or KCl by inhibiting extracellular Ca2+ entry.

Conclusion: The study demonstrates that Laurus nobilis aqueous extract exhibits potent antihypertensive and vasorelaxant activities via inhibiting Ca2+ entry.

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月桂对大鼠降压作用的研究。

目的:研究月桂的降压作用。背景:月桂在摩洛哥被用来治疗高血压。目的:研究月桂叶水提物(AELN)对血压的影响。材料与方法:采用药理学方法研究AELN对正常和l - name诱导的高血压大鼠的降压和血管松弛活性。随后测量血压，并测定该提取物的体外血管松弛活性。结果:AELN对l - name诱导的高血压大鼠血压指标有明显降低。该提取物通过抑制细胞外Ca2+进入，对肾上腺素或KCl预收缩的主动脉产生血管松弛作用。结论:月桂水提物通过抑制Ca2+的进入，具有有效的抗高血压和血管松弛作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular and Hematological Agents in Medicinal Chemistry Medicine-Cardiology and Cardiovascular Medicine

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： Cardiovascular & Hematological Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new Cardiovascular & Hematological Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Cardiovascular & Hematological medicinal chemistry. Cardiovascular & Hematological Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cardiovascular & hematological drug discovery.