Relevance and consequence of chronic inflammation for obesity development.

IF 2.4 Q1 PEDIATRICS
Lisa Ruck, Susanna Wiegand, Peter Kühnen
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引用次数: 0

Abstract

Background: Increasing prevalence of morbid obesity accompanied by comorbidities like type 2 diabetes mellitus (T2DM) led to a demand for improving therapeutic strategies and pharmacological intervention options. Apart from genetics, inflammation processes have been hypothesized to be of importance for the development of obesity and related aspects like insulin resistance.

Main text: Within this review, we provide an overview of the intricate interplay between chronic inflammation of the adipose tissue and the hypothalamus and the development of obesity. Further understanding of this relationship might improve the understanding of the underlying mechanism and may be of relevance for the establishment of new treatment strategies.

慢性炎症与肥胖发展的相关性和后果。
背景:伴随2型糖尿病(T2DM)等合并症的病态肥胖的患病率日益增加,导致对改进治疗策略和药物干预选择的需求。除了遗传学,炎症过程被认为对肥胖和胰岛素抵抗等相关方面的发展很重要。在这篇综述中,我们概述了脂肪组织和下丘脑的慢性炎症与肥胖发展之间复杂的相互作用。进一步了解这种关系可能会提高对潜在机制的理解,并可能与建立新的治疗策略相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
2.20
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0.00%
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