Prediction of SARS-CoV-2 Infection Phosphorylation Sites and Associations of these Modifications with Lung Cancer Development.

IF 3.8 4区医学 Q2 GENETICS & HEREDITY

Current gene therapy Pub Date : 2024-01-01 DOI:10.2174/0115665232268074231026111634

Wei Li, Gen Li, Yuzhi Sun, Liyuan Zhang, Xinran Cui, Yuran Jia, Tianyi Zhao

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引用次数: 0

Abstract

Introduction: Since the emergence of SARS-CoV-2 viruses, multiple mutant strains have been identified. Infection with SARS-CoV-2 virus leads to alterations in host cell phosphorylation signal, which systematically modulates the immune response.

Methods: Identification and analysis of SARS-CoV-2 virus infection phosphorylation sites enable insight into the mechanisms of viral infection and effects on host cells, providing important fundamental data for the study and development of potent drugs for the treatment of immune inflammatory diseases. In this paper, we have analyzed the SARS-CoV-2 virus-infected phosphorylation region and developed a transformer-based deep learning-assisted identification method for the specific identification of phosphorylation sites in SARS-CoV-2 virus-infected host cells.

Results: Furthermore, through association analysis with lung cancer, we found that SARS-CoV-2 infection may affect the regulatory role of the immune system, leading to an abnormal increase or decrease in the immune inflammatory response, which may be associated with the development and progression of cancer.

Conclusion: We anticipate that this study will provide an important reference for SARS-CoV-2 virus evolution as well as immune-related studies and provide a reliable complementary screening tool for anti-SARS-CoV-2 virus drug and vaccine design.

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SARS-CoV-2感染磷酸化位点的预测及其与肺癌发展的关系

自SARS-CoV-2病毒出现以来，已经发现了多个突变株。感染SARS-CoV-2病毒导致宿主细胞磷酸化信号的改变，从而系统地调节免疫反应。方法:鉴定和分析SARS-CoV-2病毒感染磷酸化位点，有助于深入了解病毒感染机制及其对宿主细胞的影响，为研究和开发治疗免疫性炎症性疾病的强效药物提供重要基础数据。本文分析了SARS-CoV-2病毒感染的磷酸化区域，并开发了一种基于转换器的深度学习辅助鉴定方法，用于特异性鉴定SARS-CoV-2病毒感染的宿主细胞磷酸化位点。结果:此外，通过与肺癌的关联分析，我们发现SARS-CoV-2感染可能影响免疫系统的调节作用，导致免疫炎症反应异常升高或降低，这可能与癌症的发生发展有关。结论:本研究将为SARS-CoV-2病毒进化及免疫相关研究提供重要参考，并为抗SARS-CoV-2病毒药物和疫苗设计提供可靠的补充筛选工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current gene therapy 医学-遗传学

CiteScore

6.70

自引率

2.80%

发文量

期刊介绍： Current Gene Therapy is a bi-monthly peer-reviewed journal aimed at academic and industrial scientists with an interest in major topics concerning basic research and clinical applications of gene and cell therapy of diseases. Cell therapy manuscripts can also include application in diseases when cells have been genetically modified. Current Gene Therapy publishes full-length/mini reviews and original research on the latest developments in gene transfer and gene expression analysis, vector development, cellular genetic engineering, animal models and human clinical applications of gene and cell therapy for the treatment of diseases. Current Gene Therapy publishes reviews and original research containing experimental data on gene and cell therapy. The journal also includes manuscripts on technological advances, ethical and regulatory considerations of gene and cell therapy. Reviews should provide the reader with a comprehensive assessment of any area of experimental biology applied to molecular medicine that is not only of significance within a particular field of gene therapy and cell therapy but also of interest to investigators in other fields. Authors are encouraged to provide their own assessment and vision for future advances. Reviews are also welcome on late breaking discoveries on which substantial literature has not yet been amassed. Such reviews provide a forum for sharply focused topics of recent experimental investigations in gene therapy primarily to make these results accessible to both clinical and basic researchers. Manuscripts containing experimental data should be original data, not previously published.