The Choroid after Half-Dose Photodynamic Therapy in Chronic Central Serous Chorioretinopathy.

Q3 Medicine

Acta medica (Hradec Kralove) Pub Date : 2022-01-01 DOI:10.14712/18059694.2022.24

Evita Evangelia Christou, Andreas Katsanos, Ilias Georgalas, Vassilios Kozobolis, Christos Kalogeropoulos, Maria Stefaniotou

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引用次数: 0

Abstract

Purpose: To characterize choroidal structure and vasculature after half-dose verteporfin photodynamic therapy (hd-vPDT) in eyes with chronic central serous chorioretinopathy using Enhanced Depth Imaging Optical Coherence Tomography (EDI OCT) and Optical Coherence Tomography Angiography (OCT-A).

Methods: This prospective case-control study included 10 eyes. Choroid was examined before and at 1 month following hd-vPDT. We measured choroidal thickness (CT) at subfoveal area and at 750 μm nasal and temporal of fovea and thickness of Haller and choriocapillaris/Sattler layers. Whole (WA), luminal (LA) and interstitial area (IA) at EDI-OCT, and perfusion density at OCT-A were analyzed. The unaffected fellow eyes were used for comparisons.

Results: Mean CT at subfoveal area and at 750 μm nasal and temporal of fovea, values of Haller and choriocapillaris/Sattler layers and those of WA, LA and IA were reduced, while PD increased at 1 month after hd-vPDT (all p < 0.001). There was a significant (p < 0.05) negative correlation (ρ = -0.658) between PD and post-treatment logMARVA. None of analyzed parameters reached values of unaffected fellow eye.

Conclusion: Following hd-vPDT, choroidal thickness with both luminal and interstitial components markedly decreased, while perfusion of choriocapillaris improved.

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慢性中枢性浆液性脉络膜视网膜病半剂量光动力治疗后脉络膜的变化。

目的:利用增强深度成像光学相干断层扫描(EDI OCT)和光学相干断层扫描血管造影(OCT- a)研究半剂量维替泊芬光动力治疗(hd-vPDT)对慢性中央性浆液性脉络膜视网膜病变后的脉络膜结构和血管系统的变化。方法:本前瞻性病例对照研究纳入10只眼。在hd-vPDT之前和之后1个月检查脉络膜。我们测量了中央窝下区和750 μm中央窝鼻部和颞部的脉络膜厚度(CT)以及Haller层和绒毛膜毛细血管/Sattler层的厚度。分析EDI-OCT的全面积(WA)、腔面积(LA)、间质面积(IA)和OCT-A的灌注密度。未受影响的同伴的眼睛被用于比较。结果:hd-vPDT术后1个月，中央凹下区、750 μm鼻部和颞部CT均值、Haller、绒毛膜/Sattler层及WA、LA、IA层值降低，PD值升高(均p < 0.001)。PD与治疗后logMARVA呈显著负相关(p < 0.05) (ρ = -0.658)。所分析的参数均未达到未受影响的同伴眼的值。结论:hd-vPDT后，管腔和间质成分的脉络膜厚度均明显降低，绒毛毛细血管灌注改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta medica (Hradec Kralove) Medicine-Medicine (all)

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： Acta Medica (Hradec Králové) is a multidisciplinary medical journal published by the Faculty of Medicine in Hradec Králové - Karolinum Press, the publishing house of Charles University. The journal is peer-reviewed and published quarterly in both paper and electronic form. The language of Acta Medica is English. Offerings include review articles, original articles, brief communications, case reports, announcements and notices. The journal was founded in 1958 under the title "A Collection of Scientific Works of the Charles University Faculty of Medicine in Hradec Kralove."