Association between the interferon-induced transmembrane protein 3 gene (IFITM3) rs34481144 / rs12252 haplotypes and COVID-19

Current research in virological science Pub Date : 2021-01-01 DOI:10.1016/j.crviro.2021.100016

Elías Cuesta-Llavona , Guillermo M. Albaiceta , Marta García-Clemente , Israel D. Duarte-Herrera , Laura Amado-Rodríguez , Tamara Hermida-Valverde , Ana I. Enríquez-Rodriguez , Cristina Hernández-González , Santiago Melón , Marta E. Alvarez-Argüelles , José A. Boga , Susana Rojo-Alba , Daniel Vázquez-Coto , Juan Gómez , Eliecer Coto PhD

{"title":"Association between the interferon-induced transmembrane protein 3 gene (IFITM3) rs34481144 / rs12252 haplotypes and COVID-19","authors":"Elías Cuesta-Llavona , Guillermo M. Albaiceta , Marta García-Clemente , Israel D. Duarte-Herrera , Laura Amado-Rodríguez , Tamara Hermida-Valverde , Ana I. Enríquez-Rodriguez , Cristina Hernández-González , Santiago Melón , Marta E. Alvarez-Argüelles , José A. Boga , Susana Rojo-Alba , Daniel Vázquez-Coto , Juan Gómez , Eliecer Coto PhD","doi":"10.1016/j.crviro.2021.100016","DOIUrl":null,"url":null,"abstract":"<div>The interferon induced transmembrane-protein 3 (IFITM3) plays an important role in the defence against viral infection. IFITM3 gene variants have been linked to differences in expression and associated with the risk of severe influenza by some authors. More recently, these variants have been associated with the risk of COVID-19 after SARS-CoV-2 infection. We determined the effect of two common IFITM3 polymorphisms (rs34481144 C/T and rs12252 A/G) on the risk of hospitalization due to COVID-19 by comparing 484 patients (152 required support in thr intensive care unit, ICU) and 182 age and sex matched controls (no disease symptoms). We found significantly higher frequencies of rs34481144 T and rs12252 G carriers among the patients (OR = 2.02 and OR = 1.51, respectively). None of the two variants were associated with ICU-admission or death. We found a significantly higher frequency of rs34481144 CC + rs12252 AA genotype carriers among the controls, suggesting a protective effect (p = 0.001, OR = 0.56, 95%CI = 0.40–0.80). Moreover, haplotype rs34481144 C - rs12252 A was significantly increased in the controls (p = 0.008, OR = 0.71, 95%CI = 0.55–0.91).Our results showed a significant effect of the IFITM3 variants in the risk for hospitalization after SARS-CoV-2 infection.</div>","PeriodicalId":72755,"journal":{"name":"Current research in virological science","volume":"2 ","pages":"Article 100016"},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666478X21000106/pdfft?md5=39328f73561396e183881376e34456df&pid=1-s2.0-S2666478X21000106-main.pdf","citationCount":"18","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current research in virological science","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666478X21000106","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 18

Abstract

The interferon induced transmembrane-protein 3 (IFITM3) plays an important role in the defence against viral infection. IFITM3 gene variants have been linked to differences in expression and associated with the risk of severe influenza by some authors. More recently, these variants have been associated with the risk of COVID-19 after SARS-CoV-2 infection. We determined the effect of two common IFITM3 polymorphisms (rs34481144 C/T and rs12252 A/G) on the risk of hospitalization due to COVID-19 by comparing 484 patients (152 required support in thr intensive care unit, ICU) and 182 age and sex matched controls (no disease symptoms). We found significantly higher frequencies of rs34481144 T and rs12252 G carriers among the patients (OR = 2.02 and OR = 1.51, respectively). None of the two variants were associated with ICU-admission or death. We found a significantly higher frequency of rs34481144 CC + rs12252 AA genotype carriers among the controls, suggesting a protective effect (p = 0.001, OR = 0.56, 95%CI = 0.40–0.80). Moreover, haplotype rs34481144 C - rs12252 A was significantly increased in the controls (p = 0.008, OR = 0.71, 95%CI = 0.55–0.91).

Our results showed a significant effect of the IFITM3 variants in the risk for hospitalization after SARS-CoV-2 infection.

Abstract Image

查看原文本刊更多论文

干扰素诱导的跨膜蛋白3基因(IFITM3) rs34481144 / rs12252单倍型与COVID-19的关系

干扰素诱导的跨膜蛋白3 (IFITM3)在防御病毒感染中起重要作用。一些作者认为，IFITM3基因变异与表达差异有关，并与患严重流感的风险有关。最近，这些变异与SARS-CoV-2感染后感染COVID-19的风险有关。我们通过比较484例患者(152例在重症监护病房需要支持)和182例年龄和性别匹配的对照组(无疾病症状)，确定了两种常见IFITM3多态性(rs34481144 C/T和rs12252 A/G)对COVID-19住院风险的影响。我们发现患者中rs34481144t和rs12252g的携带频率显著较高(OR = 2.02和OR = 1.51)。这两种变异均与icu入院或死亡无关。我们发现rs34481144 CC + rs12252 AA基因型携带者在对照组中的频率显著增加，表明有保护作用(p = 0.001, OR = 0.56, 95%CI = 0.40-0.80)。此外，单倍型rs34481144c - rs12252a在对照组中显著增加(p = 0.008, OR = 0.71, 95%CI = 0.55 ~ 0.91)。我们的研究结果显示，IFITM3变异对SARS-CoV-2感染后住院的风险有显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current research in virological science

自引率

0.00%

发文量